3D Cell Cultures Market

Global Market Study on 3D Cell Culture: Need for Lower Drug Discovery Costs during Research Heightening Demand

3d Cell Cultures Market Segmented By Scaffold-free 3D Cell Culture, Scaffold-based 3D Cell Culture, Hydrogel-based 3D Cell Culture, Polymeric Hard Material-based 3D Cell Culture Product type in Drug Discovery, Tissue Regeneration & Regenerative Medicines, Cancer Research, Stem Cell Technology Application

  • January-2021
  • PMRREP3329
  • 220 Pages
  • Healthcare

About the Report

3D cell culture has mostly been used in cancer research, as cancer cells are more responsive to culture in vitro. In addition, 3D cell culture is efficiently proficient in detecting target and non-target reactions and interactions on the candidate drug. It can help in sorting potential drug molecules and during the study of the ‘in-vitro’ conditions, 3D cell culture models mimic natural environmental conditions. Key manufacturer such as Merck KGaA, Thermo Fisher Scientific, Inc., Becton Dickinson & Company have their distribution facilities, manufacturing sites, and offices globally. Emergence of e-Commerce also aids in increasing the availability of 3D cell culture products from prominent players.

In its new study, Persistence Market Research offers insights about key factors driving demand for 3D cell culture. The study points toward Scaffold-based 3D cell culture being the most sought-after. Biotechnology and pharmaceuticals industries hold close to half the market share, globally. The report also tracks global sales of 3D cell culture in 20+ high-growth markets, along with analyzing the impact COVID-19 has on the life science industry in general, and 3D cell culture in particular. The COVID-19 pandemic will have a positive impact on demand for 3D cell culture, as these models are vital during drug development against infectious diseases.

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  • Merck KGaA (Sigma-Aldrich Corporation)
  • Thermo Fisher Scientific, Inc.
  • Corning Incorporated.
  • Becton.Dickinson and Company
  • 3D Biotek LLC.
  • Lonza Group.
  • InSphero AG.
  • Synthecon, Inc
  • Nanofiber Solutions, Inc
  • Greiner Group A

Future of 3D Cell Culture Market Even Brighter than Before

Demand for 3D cell culture has been exponentially rising since the last couple of decades, and the last few years has seen the market grow at an average of around 7%. In 1982, the first biopharmaceutical drug, Humulin, was launched. And recently, in 2019, the FDA approved 48 novel biopharmaceutical drugs.

The 3D cell culture market is growing due to the introduction of novel therapeutics, and through the release of generic biopharmaceuticals or biosimilars, which can be manufactured by numerous companies. Along with rapid growth of biopharmaceuticals, 3D cell culture is expected to witness significant traction over the forecast period. Demand for biosimilar products with 3D cell culture is anticipated to revolutionize the biopharmaceutical market.

Application of animals for testing and research has created ethical issues being highlighted by animal welfare organizations. As per the Humane Society International in 2019, 115 million animals were used for animal testing, worldwide, every year. 3D cell culture is anticipated to substitute animals for testing in laboratories. Government and non-profit organizations such as The Environmental Protection Agency, the National Toxicology Program, and the National Institutes of Health launched the ToxCast initiative, amongst others, to substitute laboratory animals with 3D cell culture. Such movements and increasing awareness create opportunities for the expansion of the 3D cell culture market size over the forecast period, which is projected to expand at a CAGR close to 10% through 2031.

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What is the Impact of Market Consolidation Activities on 3D Cell Culture Demand?

Given the union in the market, key players are focusing on strategic acquisitions at regional levels. This trend is observed across North America, Europe, and Asian countries such as China and Japan.

Acquisitions empower companies with products and increase their portfolio. The company which has been acquired possesses well-established products and solutions, which become a good revenue source for the acquirer. This also enables the company to enter new emerging markets as well as enhance existing market shares.

  • For instance, in February 2017, Thermo Fisher Scientific Inc., completed its previously announced acquisition of Finesse Solutions, Inc., a leader in the development of scalable control automation systems and software for bio production.
  • In May 2018, Greiner Bio-One acquired 3D Cell Culture Technology assets from Nano3D Biosciences, Inc.
  • In November 2015, Merck KGaA acquired Sigma-Aldrich, and became a leading player in the 3D cell culture market.

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How Does 3D Cell Culture Help Lower Drug Discovery Costs?

The conventional processes of drug discovery are less relevant and inadequate for significant growth of the life science industry. For better humanized medicines and therapeutics, 3D cell culture is effectively used to observe non-target and target reactions and interactions on the candidate drug. Moreover, 3D cell cultures are anticipated to hold significant revenue share for cancer therapeutic and drug discovery application.

Novel innovations to discriminating living tissues such as metabolic functions, nutrient transport, and respiration to accurately determine drug properties are driving 3D cell culture demand. As per a report of the International Federation of Pharmaceutical Manufacturers & Associations, more than twenty five percent expenditure is on drug discovery. Implementation of 3D cell culture for drug discovery saves money and shortens the process time, contributing to higher demand across regions.

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Why are Advanced Manufacturing Activities Key to Market Growth?

Key players in the market are focused on increasing their product features and portfolio to strengthen their position in the market, and also to expand their footprints in emerging markets. Players are entering the market with novel and innovative 3D cell culture, with features such as magnetic levitation, better respiration, and others, to differentiate themselves and generate increased revenue. Manufacturers in North America and Europe are focusing on expanding their range of 3D cell cultures by producing products specific to applications such as stem cell research, drug discovery, and spheroid tumor models.

Will Better Resemblance to in vivo Environment Increase 3D Cell Culture Sales?

The primary driver of the 3D cell culture market is considered to be the attainment of greater degree of resemblance to natural, in vivo environmental conditions. 3D cell cultures are used for cell maintenance, screening, and cell-based assays. Cell cultures in 2D environment restrain their potential to represent traits exhibited by in vivo systems, due to the locomotion and morphological barrier imposed by the 2D atmosphere. The effectiveness of 3D cell culture generates more accurate models of tissues and mimics the natural environment for culturing of cells. The wide range of application of 3D cell culture further contributes to its growing demand from end users. According to the Drug Discovery World Summer report 2017, around 60% of scientists plan to transition from 2D to 3D cell culture, due to remarkable biological relevance attained by 3D cell culture. 3D cell cultures are able to create relevant cell models and better replication of conditions of living organisms. Improved and better 3D cell culture systems are anticipated to further propel the expansion of the 3D cell culture market over the coming years.

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Country-wise Insights

Why Does Japan Witness Significant Demand for 3D Cell Culture?

Cell-based assays have been widely used in drug discovery for several decades. 3D cell culture plays a vital role in drug discovery. Japan is the 3rd-largest pharma industry in the world. In addition to this, Japan has a high number of domestic pharma companies. Furthermore, the Japanese government provides financial support for ongoing life science research. Hence, demand for 3D cell culture is high in in the country for drug development and life science research purposes.

How Will Increasing Focus on Oncological Research in the U.S Surge 3D Cell Culture?

Potentially, cell culture is the most useful in oncology research, as cancer cells are more responsive to culture in vitro. Cancer research depends on cell-based assays comprising in vitro cancer cell culture. In the preclinical stage, cell-based assays are important; the cellular model that can represent physiological and pathological conditions for cell-based assays can significantly accelerate development time, and with increasing knowledge of cellular pathways, it helps identify new targets for drug development

The National Cancer Institute (NCI) along with other institutes invests in major cancer research projects to support and facilitate research on various types of cancers, such as the NCI Genomic Data Commons (GDC), National Clinical Trials Network (NCTN), Cancer Moonshot, NCI Community Oncology Research Program (NCORP), the RAS Initiative, etc. Financial support for cancer research by government and nongovernmental organizations is growing in the country, thereby aiding the growth of 3D cell culture.

What is the Impact of Increasing Demand for Regenerative Medicine on the Indian 3D Cell Culture Market?

Regenerative medicine is a part of medicine that deals with the process to repair, replace, or regrow damaged and diseased cells, tissues, or whole organs that have been lost or disturbed due to congenital defects, aging, disease, or damage. In India, there is rising adoption of personalized medicines because growing awareness demand for better treatment options. Moreover, growing prevalence of cancer in India has surged demand for regenerative medicine. 3D cell cultures are mainly used to observe cell interactions and abnormal behavior of cells. Regenerative medicines play an important role in organ and tissue transplantation. Cell culture is a vital part of regenerative medicine. As such, increasing demand for regenerative medicine is positively impacting demand for 3D cell culture in the country.

How is the Presence of 3D Cell Culture Companies Aiding the European Union?

Germany will continue leading the 3D cell culture market in Europe, and is expected to experience significant growth over the coming years. As per Persistence Market Research analysis, France will also progress substantially in this space. Some prominent players such as Merck KGaA, Lonza, Thermo Fisher Scientific Inc., and Becton, Dickinson and Company are present in Europe, which creates notable revenue for the region. Moreover, research & development activities in Germany are also creating a surge in demand for 3D cell culture in the country. Adoption of 3D cell culture amongst researchers is higher in Germany and France as compared to other neighboring countries in the region.

Category Insights

How is Increasing Demand for Biopharmaceuticals Impacting the 3D Cell Culture Industry?

Biopharmaceuticals are medications (therapeutic items) made through genetic manipulation of living cells or organisms. With rising prevalence of infectious diseases such as bacterial and viral infections, demand for biopharmaceuticals is also growing. Specially, the gene therapy and cellular therapy section is developing and is a standout amongst the most dynamic and promising pipelines in the biopharmaceuticals market. Gradually, maximum vaccine manufacturing processes will involve the use of cell strains and cultures made up of only a single type of cell. Biopharmaceuticals have become a rapidly growing sector in the pharmaceutical industry. Above 200 biopharmaceutical products are being marketed and many more in the development phase.

Competitive Landscape

The global market is dominated by top manufacturers - Corning Incorporated, Greiner Group AG, Thermo Fisher Scientific Inc., Merck KGaA, and Becton, Dickinson and Company, Lonza. Major manufacturers are focusing on the development of a wide range of 3D cell cultures. Moreover, key players in the 3D cell culture market are focusing on enhancing their global and regional presence through acquisitions and expansion strategies.

  • For instance, on October 25, 2018, Thermo Fisher Scientific Inc. completed its previously announced acquisition of the advanced bioprocessing business of BD (Becton, Dickinson and Company), a leading global medical technology company, for US$ 477 million in cash.
  • On November 15, 2018, Lonza and Sartorius Stedim Biotech modified its relationship for the supply of cell culture media.
  • On January 29, 2018, Corning announced an agreement with Saudi Telecom Company.

Some of the leading companies operating in the market are:

  • Thermo Fisher Scientific Inc.
  • Merck KGaA
  • Becton, Dickinson and Company
  • "Lonza
  • Corning Incorporated
  • Synthecon, Inc
  • 3D Biotek LLC
  • Nanofiber Solutions, Inc.
  • Greiner Group AG
  • Lena Biosciences
  • MicroTissues, Inc.

*The list is not exhaustive, and only for representational purposes. Full competitive intelligence available in the report.

Scope of Report



Forecast Period


Historical Data Available for


Market Analysis

  • USD Million for Value
  • Units for Volume

Key Regions Covered

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia
  • Oceania
  • Middle East & Africa

Key Countries Covered

  • US
  • Canada
  • Brazil
  • Mexico
  • Argentina
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Poland
  • Russia
  • China
  • Japan
  • South Korea
  • India
  • Thailand
  • Indonesia
  • Malaysia
  • Australia
  • New Zealand
  • South Africa
  • GCC Countries

Key Segments Covered

  • Product
  • Application
  • End User
  • Region

Key Companies Profiled

  • Thermo Fisher Scientific Inc.
  • Merck KGaA
  • Becton, Dickinson and Company
  • Lonza
  • Corning Incorporated
  • Synthecon, Inc
  • 3D Biotek LLC
  • Nanofiber Solutions, Inc.
  • Greiner Group AG
  • Lena Biosciences
  • MicroTissues, Inc.


Report Coverage

  • Market Forecast
  • Company Share Analysis
  • Competition Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives

Customization & Pricing

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3D Cell Culture Market by Category

Product Type

  • Scaffold-free 3D Cell Culture
  • Scaffold-based 3D Cell Culture
    • Hydrogel-based 3D Cell Culture
    • Polymeric Hard Material-based 3D Cell Culture


  • Drug Discovery
  • Tissue Regeneration & Regenerative Medicines
  • Cancer Research
  • Stem Cell Technology
  • Others

End User

  • Biotechnology and Pharmaceuticals Industries
  • Academic Research Institutes
  • Hospital Laboratories
  • Contract Research Organizations


  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • MEA

Key Questions Answered in Report

Q1. Which is the most lucrative market for 3D cell culture?

The U.S currently leads the global market for 3D cell culture, and demand will be significant throughout the forecast period.

Q2. Which product holds significant share in the market?

Demand for scaffold-based 3D cell culture is expected to remain high in the near future, especially due to higher adaption in North America for research.

Q3. Why is 3D cell culture mostly used for cancer research?

Cancer research has gained most benefits from 3D culture, which improves the understanding of cancer biology.

Q4. Which are the leading companies offering 3D cell culture?

Some of the leading companies offering 3D cell culture are Thermo Fisher Scientific Inc, Merck KGaA, Lonza, and Corning Incorporated, among others.

Q5. Which are the challenges associated with 3D cell culture?

Challenges associated with 3D cell culture can be scaffold’s mechanical strength and degradation. Moreover, synthesizing scaffolds that possess adequate mechanical characteristics is one of the challenges encountered in tissue engineering.


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