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3d Cell Cultures Market Segmented By Products - Scaffold Free 3D Cell Culture | Scaffold Based 3D Cell Culture (Hydrogel based 3D cell culture, Polymeric Hard Material Based 3D cell Culture)
The global revenue from the 3D cell culture market stands at US$ 1.2 Bn in 2022, with the global market expected to grow at a CAGR of 9.4% to reach a valuation of approximately US$ 3.1 Bn by the end of 2033.
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Market Size (2022) |
US$ 1.2 Bn |
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Projected Market Value (2033) |
US$ 3.1 Bn |
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Global Market Growth Rate (2023-2033) |
9.4% CAGR |
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Market Share of Top 5 Countries |
66.4% |
As assessed by Persistence Market Research, scaffold based 3D cell culture products hold a market share of around 81.3% in 2022. Overall, 3D cell culture market sales account for approximately 5.5% revenue share in the global cell culture market, which was valued at around US$ 21.05 Bn in 2022.
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The global market recorded a historic CAGR of 7.4% in the last 6 years from 2016 to 2022.
In 3D cell culture, an artificial environment is created for the cells to grow in so that their behaviour in response to the environment can be studied. Creating a three-dimensional structure out of living cells that resembles tissue or an organ is known as three-dimensional cell culture (3D culture). Compared to other cell culture techniques, 3D cell culture is widely employed due to its practical and novel capabilities.
Cells are cultured on scaffolds or matrices that are designed and tailored to imitate the in-vivo extracellular matrix to generate 3D tumour and tissue models. To construct a three-dimensional cell culture, cells adhere to the scaffold, transgress into its pores, and fill them. In-vitro cell culture can use the scaffolds as a physical support system.
Due to the fact that cancer cells respond better to in vitro culture, cell cultures have aided numerous oncology studies. In vitro cancer cell culture is a key component of cell-based assays used in cancer research. The importance of cell-based assays in the preclinical stage can be attributed to two factors:
Thus, increasing focus on oncology research has provided traction to the overall market for 3D cell cultures. Additionally, the National Cancer Institute (NCI) invests in significant research initiatives, together with other institutes, to facilitate and support research on particular topics crucial to the cancer research enterprise, such as NCI Genomic Data Commons (GDC), Cancer Moonshot, The National Clinical Trials Network (NCTN), NCI Community Oncology Research Program (NCORP), the RAS Initiative, etc.
The accomplishment of a higher degree of similarity to the natural, in vivo environmental conditions is also believed to be the primary driver of the 3D cell culture market. For cell upkeep, screening, and cell-based tests, 3D cell cultures are utilised. The market for 3D cell cultures is speculated to be fuelled by the ability of these cultures to successfully cultivate cells in a manner that closely resembles their natural environment and to generate more accurate model of tissues. The numerous uses for 3D cell culture also help to fuel the market's expanding end-user demand.
Thus, owed to the above-mentioned factors, the global market is likely to show high growth over the coming years at a CAGR of 9.4% and reach a global market size of US$ 3.1 Bn by 2033.
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Numerous projects and campaigns have been started in response to the contentious subject of using animals in research and testing. Worldwide, laboratories utilise more than 115 million animals for research each year, according to Humane Society International. It is anticipated that 3D cell culture would replace animals in laboratory testing.
Animal testing is increasingly being replaced with 3D cell culture. By implementing regulations and guidelines that restrict the use of animals in testing and encourage the use of 3D cell culture instead, the market for 3D cell culture is also gaining more support and initiatives.
Additionally, several other governmental and non-profit organisations, including the National Toxicology Program, the Environmental Protection Agency, and the National Institutes of Health established the ToxCast initiative, are also working to replace laboratory animals with 3D cell cultures. Over the forecast period, such developments and rising awareness present chances for the 3D cell culture market to grow.
Since the previous few decades, the demand for 3D cell culture and related products has increased tremendously. Humulin, the first biopharmaceutical drug, was introduced in 1982. The FDA approved 48 new biopharmaceutical drugs in 2019.
The development of innovative treatments and the availability of generic biopharmaceuticals, also known as biosimilars, which can be produced by a wide range of businesses, are driving the growth of the 3D cell culture market. The market for 3D cell culture is anticipated to experience significant acceleration over the course of the projection period in addition to the biopharmaceuticals sector's rapid growth. It is projected that the need for biosimilar medicines made using 3D cell culture would completely transform the biopharmaceutical industry.
“Lack of Investments and Shortage of Skilled Professionals”
Skilled people can help innovation and growth in research and development by generating new knowledge in the field. Unfortunately, there is a scarcity of qualified individuals working on R&D initiatives. Low pay scales, challenging work, and insufficient laboratory training are some of the primary causes of a shortage of trained experts. Handling 3D cell culture necessitates specialised laboratory training courses, which are mandatory.
These expensive courses may impede the growth of the 3D cell culture market. Furthermore, a lack of expertise in research labs as a result of a lack of awareness about 3D cell culture training programmes impedes the market's expansion for 3D cell culture.
The lack of laboratory equipment brought on by inadequate government investment in research is also anticipated to restrain the market's expansion for 3D cell culture. Therefore, a lack of individuals with the necessary skills and a shortage of the equipment and other resources required in research labs could have a detrimental effect on the market for 3D cell culture.
Compared to conventional 2D cell culture, 3D cell culture offers a model that more closely resembles cell-to-cell interactions, but it still lacks a properly functioning vascular system. Scaffolds are crucial in 3D cell culture because they support the developing cells. These tissue engineering scaffolds can be used for osteochondral structures, soft tissues, and even hard tissues to repair, regenerate, and biofabricate them.
The final observed result of the procedure is largely dependent on the porosity, surface to volume ratio, and pore dispersion. One of the problems with tissue engineering is the difficulty of synthesising scaffolds with acceptable mechanical properties. Furthermore, porosity is absent in a lot of materials with good mechanical strength. Lack of desirable scaffold characteristics could thus limit market expansion.
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Why is the U.S. Market Booming?
“Rising R&D and Large Patent Portfolio”
The U.S. is set to account for around 38.4% share in the global market in 2023.
The nation is concentrating on R&D and has spent a lot of money over the past ten years on 3D cell culture. The nation has seen technological improvements as a result. Among the top patent applications for the field of 3D cell culture are numerous U.S. applicants. American applicants typically develop their innovations both in the United States and in Asia.
Over the past few years, the nation's bioengineering industry has also seen significant investment. Research on 3D cell culturing is a part of bioengineering. The presence of foreign funding agencies and the region's growing infrastructure have both contributed to the rise in demand for 3D cell cultures.
Will Germany Be a Lucrative Market for 3D Cell Culture?
“Rising Awareness Initiatives and Technology Adoption in Regenerative Medicine”
Germany is set to hold around 6.8% share of the global market in 2023.
As part of their efforts to increase public knowledge of 3D cell cultures and the country's 3D cell culture market, a number of organisations and institutes in Germany that are involved in 3D cell culture also run training programmes and seminars. The market for 3D cell culture in Germany is expanding as a result of conferences held to encourage the adoption of this technology and financial support provided by the government for biological research.
Innovations in regenerative medicine and stem cell research have shown promise in the treatment of fatal diseases and other similar conditions. In Germany, stem cell therapies and regenerative medicine are widely adopted. Additionally, the nation has a strong healthcare infrastructure. These elements support the country's overall market growth over the forecasted years.
How is India Emerging as a Prominent Market?
“Rising Contract Research Activities and Research in Stem Cell Therapies”
India is set to project a CAGR growth at around 11.3% during the forecast period.
India is placing more and more emphasis on R&D in the healthcare industry. The nation is home to various contract research organisations that work on numerous projects for oncology, stem cell, and regenerative medicine studies. In comparison to developed countries throughout the world, regulatory practises in the nation are less stringent. Since umbilical cords are readily available and have no ethical issues when it comes to obtaining stem cells, the businesses in this industry leverage them for stem cell research.
Due to their pluripotent nature, stem cells are thought to be beneficial in treating a variety of blood-related disorders. As a result, they are used to address the rising demand for medical care from patients. Thus, the development of the 3D cell culture market in India would benefit from the developments in stem cell therapy.
Which Product is Driving Demand within the Global Market?
“Applications in Personalized Medicine”
Scaffold based 3D cell culture products hold around 81.3% value share of the total market in 2022. Cells are embedded into the matrix in scaffold-based 3D cultures, and the chemical and physical qualities of the scaffold material will affect the characteristics of the cells. In order to screen various drugs, evaluate drug efficacy on patient samples, and pave the road for individualised therapy, 3D-based scaffolds are excellent resources for cultivating primary patient-derived cancer cells.
In comparison to various suspension culture techniques, gel embedding and scaffolds have several advantages in simulating the 3D structure of tumour cells in vivo as they are more precise at simulating the complete range of micro - environmental signals, including three dimensional cell-cell and cell-extracellular matrix interactions.
Which Application is Largely Adopted within the Global Market?
“Application of 3D Cell Cultures in Ex-Vivo Tumour Studies”
Cancer research applications held around 31.1% of the total market share in 2022.
Understanding the intricate physiology of malignancies has benefited greatly from the study of cancer cell lines. They provide uniform samples without individual variances and can be used with simplicity and flexibility, making them great study materials. The development of 3D cell culture techniques has also added a new dimension to cancer research. This method multiplied the ways in which cancer cell lines may be used to comprehend the complex biology of cancer.
Particularly in the domain of drug sensitivity, which is one of the fundamental concepts of translational medicine, 3D cell culture offers a suitable platform for further defining the biological properties of tumour cells.
Which End User Provides the Global Market With a Large Share?
“Advances in Drug Development and Tissue Engineering”
The biotechnology and pharmaceuticals industries segment held a revenue share of about 43.8% in 2022.
Due to its obvious benefits in delivering more physiologically relevant information and more accurate information for in vivo studies, three-dimensional (3D) cell culture techniques have attracted growing interest in drug development and tissue engineering.
With the growing cases of chronic and infectious diseases worldwide, there is a demand for personalized therapies, as well as growing research on novel biologics. Companies are catering towards contract research and production activities for their products. Moreover, several manufacturers are developing new production approaches for their pipelined products, these factors propel the segment of biotechnology and pharmaceutical industries as the prime end user segments within the global market.
Manufacturers mostly use partnerships, launches, expansions, mergers, and acquisitions to boost sales across various geographies enhancing product portfolio via new product lines and R&D expenditures. Businesses are making significant R&D investments to diversify their product offerings and increase their global market presence, particularly to meet the changing demands of researchers.
Some key instances of development within the market include:
Similarly, the team at Persistence Market Research has tracked recent developments related to companies in the 3D cell culture market, which are available in the full report.
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Attribute |
Details |
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Forecast Period |
2023-2033 |
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Historical Data Available for |
2016-2022 |
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Market Analysis |
USD Million for Value |
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Key Countries Covered |
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Key Market Segments Covered |
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Key Companies Covered |
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Report Coverage |
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Customization & Pricing |
Available upon Request |
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The global market is currently valued at around US$ 1.2 Bn in 2022.
Sales of the market are set to witness growth at a CAGR of 9.4% and be valued at around US$ 3.1 Bn by 2033.
Demand for the global market increased at a 7.4% CAGR from 2016 to 2022.
The U.S, Japan, Germany, France, and China account for most demand within the market, currently holding around 66.4% market share.
The U.S. is set to account for around 38.4% share of the global market in 2023.
Europe is set to account for around 27.1% share of the global market in 2023.
The Japan market is expected to hold a share of more than 11% in the global market in 2023.
Germany is set to hold around 6.8% share of the global market in 2023.
China market is expected to grow at 10.7% CAGR during the forecast period.
The market in India is set to expand at an 11.3% CAGR over the forecast period.
