Global Market Study on Pyrogen Testing: Animal-free Testing Methods Setting a New Trend

Pyrogen Testing  Market
  • Published On : Sep-2019 |
  • Pages : 146 Pages |
  • Format : Pyrogen Testing  Market Pyrogen Testing  Market Pyrogen Testing  Market Pyrogen Testing  Market

Increase in the number of people diagnosed with chronic diseases drives the demand for pyrogen testing. For instance, in 2012, around 220 million people were affected by chronic diseases and approximately 85% of them required monitoring on a regular basis. Furthermore, it has been estimated that 75% to 80% of the total deaths, in low economies, occur due to chronic conditions and thus, the increasing prevalence of chronic diseases seems to be directly impacting the growth of the global pyrogen testing market. The market for global pyrogen testing is expected to grow at a robust 9% CAGR through 2029, as indicated by a recent forecast study.

Pyrogens, being fever inducing organic substances, play a vital role when dealing with different diseases. Pyrogen testing, especially limulus amebocyte lysate (LAL) testing, is highly recommended, and is an integral part of pharmaceutical microbiology to test bacterial endotoxin. Rising demand for such in vitro assays to detect the presence and concentration of bacterial endotoxins in biological products and drugs is expected to drive the growth of the market for pyrogen testing.

Pyrogen testing is an imperative and mandatory process, which is performed in drug and medical device manufacturing units. Pyrogen contamination is usually present in both drugs and medical devices, which can be sometimes responsible for infecting patients with certain life-threating conditions. Pyrogen testing protocol is thus necessary, and continues to drive the market for pyrogen testing globally.

Increasing R&D Investments and Drug Approvals to Aid Pyrogen Testing Market Growth

R&D is a capital intensive sector, owing to long process of development and approval cycles. It has been observed that there is an increase in the number of new drugs entering the market, as approvals by the U.S. FDA has increased in the recent past. Before a parental drug is launched into a market, it has to undergo pyrogen testing to test for presence of certain endotoxins (pyrogens). Therefore, a number of pyrogen testing assays are available in the market that aid these drug manufacturing companies in making their products safer.

A recent trend among the biopharmaceutical companies observes an increase in the new drug approvals in the areas of high unmet needs. In addition, the regulatory authorities such as FDA has also undertaken number of steps to enhance the first action approval rate. Thus, with the increase in number of drug approvals, the demand for pyrogen testing will grow and will continue to drive the market in the forecast period.

Rising Healthcare Awareness to Create Lucrative Opportunities

Advancements in the field of medicine, are among other factors leading to an increase in life expectancy, with an average reaching above 50 years. Number of people aged 50 years and above is projected to reach 83 million by the end of 2050. The geriatric population is highly susceptible to various illnesses that require continuous medical interventions. This in turn is projected to result in higher demand for pyrogen testing in the forecast period. Certain immune response such as rise in body temperature is commonly seen in onset of many chronic and acute diseases. Rise of such diseases in elderly population gives boost to market growth of pyrogen testing.

Moreover, increasing per capita healthcare expenditure is also likely to increase the growth of the pyrogen testing market. For instance, over the past few decades, global per capita healthcare expenditure has almost doubled due to the growing rate of awareness regarding pyrogen testing. Increasing healthcare spending is expected to result in rising demand for better quality pharmaceuticals and medical devices, and in turn will create lucrative growth opportunities for market players in the global pyrogen testing market.

Preference for Animal-free Pyrogen Testing Methods to Set a New Trend

Companies are focusing on development of various animal-free pyrogen testing methods such as monocyte activation assay (MAT) to overcome limitations of rabbit pyrogen testing method and LAL test, and to propagate humane treatment of animals. MAT provides high level of reliability, and also stimulates fever reaction better than rabbit pyrogen testing method.

However, unlike the LAL test, the MAT pyrogen testing method is not limited exclusively to endotoxin detection, but is highly effective in detecting both endotoxin and non-endotoxin contamination. This change in the pyrogen testing scenario is expected to bring more opportunities for the market and bring a drift in the revenue generation for players in the pyrogen testing market.

Analysts’ Viewpoint

An extensive analysis on the pyrogen testing market has resulted for our analysts to conclude that the pyrogen testing industry is growing at a notable pace, with North America and Europe dominating the worldwide market demand for pyrogen testing and its applications. The rising number of drug manufacturing industries and biotechnology companies adds to the increasing need of pyrogen testing and thus anticipated to provide huge growth opportunities for the key players in the pyrogen testing market.

The latest publication by Persistence Market Research (PMR) on the global pyrogen testing market evaluates opportunities and current market landscape, and provides detailed analysis and updates about corresponding sections affecting the global pyrogen testing market. The study offers detailed insights on the key market dynamics, which includes drivers, restraints, trends, opportunities, and comprehensive information on the market structure of pyrogen testing. The principal aim of the market study is to present exclusive information about how the market will perform in the forecast period of 2019-2029.

Important indicators for the successful growth of the pyrogen testing market are presented in this comprehensive report, which include supply chain analysis, value chain analysis, Year-on-Year (Y-o-Y) growth analysis of the market, and compounded annual growth rate (CAGR) is also described in the current PMR's research in an exhaustive way. This research study can support readers to know the demand for pyrogen testing's quantitative development opportunities over the study period.

The research is beneficial for shareholders in pyrogen testing, including pyrogen testing market investors, manufacturers, distributors, and suppliers, and can help them in developing suitable business strategies to flourish in the pyrogen testing market. The insights and wisdom presented in this PMR’s study can be leveraged by shareholders in the pyrogen testing market, industry experts, investors, researchers, reporters, as well as pyrogen testing business enthusiasts.

Market statistics as well as information linked to macro as well as microeconomic variables affecting business scenario in the pyrogen testing market are also included in the current study. Depending on potential developments in the pyrogen testing market, substantive insights are also encountered in this report. Additionally, by virtue of the data submitted in this pyrogen testing report, minor companies and new entrants in the pyrogen testing industry can aid in making suitable company choices to achieve traction in the pyrogen testing market.

Key Segments of the Pyrogen Testing Market

PMR’s research on the pyrogen testing market provides information organized in four critical segments - test type, application, end user, and region. This report compiles extensive market research information and data on the important business dynamics and development parameters linked with these classifications.

Test type


End user


Recombinant Factor C Assay

Injectable Therapeutics

Pharmaceutical Companies

North America

Monocyte Activation Assay (MAT)


Biotechnology Companies

Latin America

Limulus Amebocyte Lysate Test (LAL)

Orally Dosed Pharmaceuticals

Medical Device Companies


Rabbit Pyrogen Test

Implantable Medical Devices


Asia Pacific




Middle East and Africa

Key Questions Answered in PMR’s Pyrogen testing Market Report

  • Which variables could alter the demand for pyrogen testing during the evaluated and forecast period?
  • What are the restraints that investors need to be aware of and might tackle while investing in the pyrogen testing market?
  • What are the trends in pyrogen testing sector that will impact the market?
  • Which business approaches are the key companies taking to prosper in the pyrogen testing market?
  • Which regions will stay the most lucrative markets for market participants in pyrogen testing?
  • How businesses in the pyrogen testing market can avail the growth opportunities in developed and emerging sectors?

Pyrogen testing Market: Research Methodology

PMR is committed to provide unbiased market research solutions to its clients. A distinctive research methodology has been used to perform comprehensive research on the development of the pyrogen testing market, and to achieve findings on the market's potential development parameters. This study design is a composition of primary and secondary research that enable analysts to ensure findings are accurate and reliable.

During the development of the pyrogen testing market report the secondary studies referred by analysts comprises of companies annual reports_bk_01_01_2020, trade journals, white papers, statistics from governmental institutions, and internal and external proprietary databases as well. Analysts have also considered opinions from product portfolio managers, and industry experts, who contributed primary insights for the development of this report.

Comprehensive data obtained from primary and secondary resources functions as an affirmation by companies in the pyrogen testing market, making PMR’s assessment of the market’s development opportunities for the pyrogen testing market more precise and credible.

Companies covered in Pyrogen Testing Market Report

Company Profiles:

  • Thermo Fisher Scientific, Inc.
  • Merck & Co., Inc.
  • Associates of Cape Cod, Inc.
  • Charles River Laboratories, Inc.
  • GenScript
  • Lonza
  • Hyglos GmbH
  • Wako Chemicals USA, Inc.
  • Microcoat Biotechnologie GmbH


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