Global Market Study on Humanized Liver Mice Model: Application in New Drug Development for Liver Cancer to Support Growing Demand for In-vivo Toxicity Testing


Humanized Liver Mice Model  Market
  • Published On : Nov-2018 |
  • Pages : 198 Pages |
  • Format :

A recent market study published by the company – “Humanized Liver Mice Model Market Global Industry Analysis 2013 – 2017 and Forecast 2018 – 2026” consists a comprehensive assessment of the most important market dynamics. On conducting a comprehensive research on the historic as well as current growth parameters of the Humanized Liver Mice Model market, the growth prospects of the market are obtained with maximum precision. The report features unique and salient factors that are likely to have a high impact on the development of the Humanized Liver Mice Model market during the forecast period. It can help market players modify their manufacturing and marketing strategies to envisage maximum growth in the Humanized Liver Mice Model market in the upcoming years. The report provides detailed information about the current and future growth prospects of the Humanized Liver Mice Model market in the most comprehensive manner for the better understanding of readers.

Chapter 1 – Executive Summary

The report commences with the executive summary of the Humanized Liver Mice Model market report, which includes the summary of key findings and key statistics of the Humanized Liver Mice Model market. It also includes the market value (US$ million) estimates of the leading segments of the Humanized Liver Mice Model market.

Chapter 2 – Market Overview

Readers can find detailed taxonomy and the definition of the Humanized Liver Mice Model market in this chapter, which helps them understand the basic information about the Humanized Liver Mice Model market dynamics, opportunity analysis, list of key distributors & suppliers, list of key market participants, epidemiology study, and patent assessment.

Chapter 3 – North America Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

This chapter includes a detailed analysis of the growth of the North America Humanized Liver Mice Model market along with a country-wise assessment that includes the U.S. and Canada. Readers can also find market growth and market attractiveness analysis based on model, application, end user and country of the Humanized Liver Mice Model in the North American region.

Chapter 4 – Latin America Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

Readers can find detailed information about the growth of the Latin America Humanized Liver Mice Model market. This chapter also includes the growth prospects of the Humanized Liver Mice Model market in leading LATAM countries such as Brazil, Mexico and the rest of the Latin America region.

Chapter 5 – Europe Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

Important growth prospects of the Humanized Liver Mice Model market based on its model, applications and end user in several European countries, such as U.K., Germany, France, Italy, Spain, Russia and rest of Europe, are included in this chapter.

Chapter 6 – Asia Pacific Excluding China (APEC) Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

India, Japan, ASEAN, Australia and New Zealand are the leading countries in the APEC region, which are the prime subjects of assessment to obtain the growth prospects of the APEC Humanized Liver Mice Model market in this chapter. Readers can find detailed information about the growth parameters of the APAC Humanized Liver Mice Model market during the period 2018-2026.

Chapter 7 – China Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

Readers can find detailed information about the growth parameters of the China Humanized Liver Mice Model market during the period 2018-2026 in this chapter.

Chapter 8 – Middle East & Africa (MEA) Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026

This chapter provides information about how the Humanized Liver Mice Model market will grow in the major countries in the MEA region, such as GCC Countries, South Africa and the rest of MEA, during the period 2013-2026.

Chapter 9 – Competition Landscape and Company Profiles

In this chapter, readers can find a comprehensive list of all the leading stakeholders in the Humanized Liver Mice Model market along with detailed information about each company, including company overview, revenue shares, strategic overview and recent company developments. Market players featured in this report include Yecuris Corporation, PhoenixBio Group, Beijing Vitalstar Biotechnology Co. Ltd., Hera BioLabs, Taconic Biosciences, Inc., University of Massachusetts Medical School, Oncodesign, University of Nebraska Medical Center and Jackson Laboratory.

Chapter 10 – Global Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026, By Model

Based on the Model, the Humanized Liver Mice Model market is segmented into uPA-SCID Mice, FRG KO Mice, TK-NOG Mice and Other Models. In this chapter, readers can find information about the key trends and developments in the Humanized Liver Mice Model market and market attractive analysis based on the model type.

Chapter 11 – Global Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026, By Application

Based on the application, the Humanized Liver Mice Model market is segmented into pharmacokinetics studies, In-vivo liver toxicity tests, drug metabolism studies and other applications. In this chapter, readers can find information about the key trends and developments in the Humanized Liver Mice Model market and market attractive analysis based on the application.

Chapter 12 – Global Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026, By End User

Based on the end user, the Humanized Liver Mice Model market is segmented into pharmaceutical companies, biotechnology companies, CRO’s and academic & research institutes. In this chapter, readers can find information about the key trends and developments in the Humanized Liver Mice Model market and market attractive analysis based on the end user.

Chapter 13 – Global Humanized Liver Mice Model Market Analysis 2013–2017 and Forecast 2018–2026, By Region

This chapter explains how the Humanized Liver Mice Model market will grow across various geographic regions, which include North America, Latin America, Europe, Asia-Pacific (APAC) and the Middle East & Africa (MEA).

Chapter 14 – Assumptions and Acronyms

This chapter includes a list of acronyms and assumptions that provide a base to the information and statistics included in the report.

Chapter 15 – Research Methodology

This chapter helps readers understand the research methodology followed to obtain various conclusions, important qualitative information and quantitative information about the Humanized Liver Mice Model market.

Rising Incidence of Liver Cirrhosis

Liver cirrhosis is the end stage of different chronic liver diseases. The prevalence of liver cirrhosis is growing due to the increasing burden of risk factors that include Hepatitis B virus (HBV) and hepatitis C virus (HCV) and liver cancer. Globally, 257 million people were infected with chronic HBV in 2015. Asia and Africa were the two continents with high endemic, an overall prevalence of over 8%. Liver cancer is the 7th most common type of cancer according to Glococan 2018. Around 841,080 people are diagnosed with liver cancer ever year globally. With the increase in prevalence of liver cirrhosis globally the number of studies based on treatment for such conditions is also increasing, which is expected to drive the growth of the humanized liver mice model market.

Technological Advancement and Development of New Humanized Liver Mice Models

A number of research studies are focused on developing new humanized liver mice models. Initially liver mice models were developed by using simple immunedeficient mice implanted with human liver cells or hepatic cancer cells. However, the results were not consistent and not reliable. This led to the development of immunedeficient mice that naturally destroy the mice liver allowing the human liver cells to grow and replace to form stable humanized liver mice models. For instance, a number of research-based studies are exploring the use of PPARalfa and AFC8-based mice models for the development of humanized liver mice model. Another humanized liver mice model known as the hPXR/CAR/CYP3A4/ 2D6/2C9 mouse has 33 mouse genes replaced with human genetic counterparts. Furthermore, with advancement in genetic technology there is a better scope of developing new genetically engineered humanized liver mice models. One such example is the CRISPR technology.

Increasing Number of FDA Approvals for Hepatitis Drugs

The increasing number of drug approvals indirectly indicates the volume of research and toxicity studies including pre-clinical studies with disease animal models including humanized liver mice model. Although there are not many liver disease-associated drugs approved by the FDA in the past few years, the frequency of drug approvals is increasing. For instance, only 4 drugs were approved from 2011 to 2014 for hepatitis treatment. However, within the span of 3 years (2015–2017) there were about 8 approvals for the same.

High Cost of Humanized Liver Mice as well as High Cost of Shipping

The cost of humanized liver mice is significantly high. The high cost of the humanized liver mice model is expected to hinder the growth of the humanized liver mice model market. For instance, the immunedeficient mice used for liver studies through grafting are available in the range of US$ 140–500, whereas chimeric humanized liver mice with 75–90% of human hepatocyte replacement, cost about US$ 2500–3500. Furthermore, there is generally an added cost of shipping that can vary based on the distance. With the requirement of specialized shipping containers and shipping protocols, the overall cost of shipping adds to the cost of the mice itself resulting in an expensive humanized liver mice model.

Focus on 3Rs is Changing the View on Use of Animals for Testing  

Animal studies follow a principle called the ‘3Rs’ – replace, reduce and refine. 3Rs is a policy that provides a framework for humane research. Replacement of animal models allows use of alternatives such as 2D & 3D cell lines or lab-on-chip devices such as the liver on chip device. It is recommended to reduce the number of animals used for experiment through careful consideration of statically methods and experiment protocol. With the introduction of the 3Rs there is a pressure on the use of animal models in experiments so as to minimize animal suffering without compromising on the statistics of the experiment or research.

humanized liver mice model market

Competitive Landscape

This section of the report profiles of key players operating in the humanized liver mice model market based on their differential strategies, product offerings marketing approaches, and company dashboard. Examples of some of the key players featured in the report include Yecuris Corporation, PhoenixBio Group, Beijing Vitalstar Biotechnology Co. Ltd., Hera BioLabs, Taconic Biosciences, Inc., University of Massachusetts Medical School, Oncodesign, University of Nebraska Medical Center and Jackson Laboratory.

Definition

Humanized mice models are mice that carry functioning human genes, cells, tissue, and/or organs. There are many ways to achieve humanized mice models through gene editing and replacement of mice liver cells with human liver cells. Most of the companies offer humanized liver mice with the replaced human liver cells or may have models that require grafting by the buyer. These humanized liver mice models include uPA-SCID Mice, FRG KO Mice, TK-NOG Mice and others. The uPA-SCID, FRG KO and TK-NOG mice represent high chimerism with 70–90% of mice liver cells replaced with human liver cells.

About the Report

PMR conducted a research on humanized liver mice model market for the forecast period of 2018 to 2026. The report offers a comprehensive evaluation of the business opportunities prevailing in the humanized liver mice model market along with insights on the consumption trend, disease incidence, and humanized liver mice model market competition. The report elaborates the macroeconomic factors influencing the dynamics of humanized liver mice model market and its futuristic potential.

Segmentation

The report offers a comprehensive taxonomy of humanized liver mice model market based on model, application, end user and region. The types of models include uPA-SCID Mice, FRG-KO Mice, TK-NOG mice and other models. Based on application, the humanized liver mice model market is segmented into pharmacokinetics studies, in-vivo liver toxicity testing, drug metabolism studies, other applications.

Additional Questions Answered

Some of the additional questions addressed in the report for humanized liver mice model market-

  • What is the revenue potential for humanized liver mice model market across regions of North America and Europe?
  • What are major challenges influencing the growth of humanized liver mice model market?
  • How intervention from regulatory authority is shaping the humanized liver mice model market growth?
  • What is the average price of humanized liver mice model?

Research Methodology

Supply-demand approach has been used to estimate the humanized liver mice model market. Humanized liver mice model sale volume was first calculated for arriving the humanized liver mice model market value in different region/countries. Research activities in the top 20 countries globally were considered for the estimation of the volume of the humanized liver mice model market. Some of the other qualitative factors considered for the estimation of volume include government funding, regulatory support and other such factors. Primary research was conducted to validate the information. Primary research included interviews, surveys, in-person interactions, and viewpoints of seasoned analysts. Secondary research such as verified paid sources, authentic trade journals, and resourceful databases were also used for validating the information. Top trends as well as macro and micro economic factors were assessed to shape the humanized liver mice model market. The report on humanized liver mice model projects the industry attractiveness of all the major segments over the forecast period.

Company Profiles

  • Taconic Biosciences, Inc.
  • Beijing Vitalstar Biotechnology Co., Ltd.
  • Yecuris Corporation
  • PhoenixBio Group
  • In-Vivo Science Inc.
  • The Jackson Laboratory
  • University of Massachusetts Medical School(Mueller Lab)
  • Oncodesign
  • University of Nebraska Medical Center
  • Others.
Back To Top