Perfusion Bioreactors Market

Global Market Study on Perfusion Bioreactors: Biopharmaceutical Companies to Remain Largest End User by Far

Perfusion Bioreactors Market Segmented by Small Scale, Large Scale Perfusion Bioreactors for R&D, GMP

  • June-2021
  • PMRREP14398
  • 268 Pages
  • Healthcare

Key Questions Answered in Report

  • What is the expected growth rate for the perfusion bioreactors market through 2031?

    By value, Persistence Market Research has projected US$ 664.5 Mn for perfusion bioreactor sales in 2031.

  • Which are the most lucrative markets for perfusion bioreactor manufacturers?

    Germany, France, Russia, Spain, and the U.S. are markets expanding at high CAGRs. Together, Europe and North America are projected to hold around 50% market share by 2031.

  • Who are the prominent manufacturers of perfusion bioreactors?

    Top suppliers of perfusion bioreactors include tier-1 companies such as Sartorius, Cytiva (Danaher Corporation), Cell Culture Company, Eppendorf AG, and Infors HT, who account for approx. 70% market share.

Find Out More about the Report Coverage


  • Sartorius AG
  • Cell Culture Company
  • Cytiva (Danaher Corporation)
  • SyntheconInc
  • Getinge (Applikon Biotechnology B.V)
  • Zellwerk GmbH
  • Thermo Fisher Scientific Inc

Report Also Addresses:

  • Market Estimates and Forecasts (2016-2031)
  • Key Drivers and Restraints Shaping Market Growth
  • Segment-wise, Country-wise, and Region-wise Analysis
  • Competition Mapping and Benchmarking
  • Brand Share and Market Share Analysis
  • Key Product Innovations and Regulatory Climate
  • COVID-19 Impact on Perfusion Bioreactors and How to Navigate
  • Recommendation on Key Winning Strategies

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Sales of Perfusion Bioreactors from 2016 to 2020 Vs Market Projections for 2021 to 2031

Historically, from 2016 to 2020, use of perfusion bioreactors increased at around 6.9% CAGRwherein, developed countries such as the U.S., Brazil, Germany, U.K., and Spain held significant share in the global market.

Growing demand for more efficiency, lower cost products, and greater productivity are resulting in a boost for bioreactors. Perfusion bioreactor technologies will be the next revolution in bioprocessing. Due to advanced technology, perfusion bioreactors can beat fed-batch bioprocessing in speed of manufacture, productivity, and capital requirements.

In recent years, technology advancements in commercial-scale and clinical bioreactors have occurred, particularly in single-use bioreactor-based systems. These innovations resulted into rising adoption of perfusion bioreactors for commercial product manufacture for products.

Increasing demand for bio-therapeutics has led to the introduction of process analytical technologies and quality-by-design concepts by regulatory bodies. These concepts aim to measure, analyze, and monitor bioprocess parameters to improve the quality of biopharmaceuticals. Due to tremendous technological advancements in bioreactors, the market is expected to expand at around 7.5% CAGR over 2021-2031.

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What are the Key Opportunities for Perfusion Bioreactor Suppliers?

Increasing investments in life sciences R&D are fueling adoption of capital-intensive combined technologies. Along with this, technology transfer has led to the development of fully automated analyzers for bioprocessing. This has increased the adoption of bioprocess equipment by manufacturers due to their high throughput and use of limited resources.

Technology transfers have a huge impact on biopharmaceutical companies in developing economies, as they increase manufacturing capacity and reduce manufacturing costs.

Due to growing competition, manufactures are focusing on developments to stay ahead. Hence, they come up with innovative ideas to get cost-effective perfusion bioreactors. New advanced product development that is non-toxic to cell culture during bioprocessing is also expected to create growth opportunities for perfusion bioreactors in the near future.


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What are the Factors Restraining Demand for Perfusion Bioreactors?

The price of instrumentation has been continuously increasing due to rise in raw material cost and demand. The cost of perfusion bioreactors is very high. This will limit their penetration in developing and low-income countries, which will hamper overall market growth to some extent.

What is the Impact of Market Consolidation on this Space?

Key players are aiming at mergers, acquisitions, and expansion, which creates opportunities in the market and also consolidates the market. Moreover, leading manufacturers are also focusing on improving their manufacturing facilities.

  • For instance, in 2020, Sartorius successfully finalized the acquisition of selected life science businesses of Danaher Corporation.

Country-wise Insights

What Makes the U.S. the Largest Market for Perfusion Bioreactors?

The U.S. is leading in North America with a market share of 89% in2021,with stable growth projected till 2031. The overall market is expected to witness steady growth owing to increasing research & development of novel biologics and new approvals of biological products.

Increasing adoption of CMO/CDMO services is also driving market growth. Also, government support for new and ongoing clinical research is driving demand for perfusion bioreactors in the U.S.

Why is Demand for Perfusion Bioreactors Flourishing in the U.K.?

The U.K is expected to show linear growth with a market share of 17.2% in Europe, and will continue to grow rapidly over the forecast period. The U.K. healthcare system is essentially financed by the government.

In recent years, potential technology advancements in commercial-scale and clinical bioreactors have occurred, particularly in single-use bioreactor-based systems. These innovations have resulted in rising adoption of perfusion bioreactors for commercial product manufacturing for products in the pipeline in the U.K.

Why is Innovation Key to Succeed in the Germany Market for Perfusion Bioreactors?

Germany has a market with share over 18% in Europe. All new technology used in research is largely adopted by this country. Perfusion-based bioreactors offer ease of continuous culturing of cells without the problem of low throughput or filter clogging, and are largely adopted by research & development centers in the country.

What Factors Make China a Lucrative Market for Perfusion Bioreactors?

China holds the largest market share of 47% in the East Asia region. In China, high population and enormous growth potential of emerging markets are the two factors driving market expansion. Most pharmaceutical players are particularly focusing on emerging markets such as China.

However, local competition and lack of established regulatory policies are some of the barriers for global manufacturers to enter the market. Also, the governments is promoting local manufacturing bases.

Will Increasing Focus on Research Surge Demand for Perfusion Bioreactors in India?

India holds the largest share in South Asia at 29.3%, and is expected to rise at a CAGR of over 7% through 2031Rising affluence, improved access to healthcare services, lifestyle changes, and rise in demand for quality healthcare are complementing market growth here.

According to the report, India generated the highest revenue among the countries in South Asia, and is set to lead the market over the coming years.

Category-wise Insights

Why is Demand for Small Scale Bioreactors (< or = 1,000 liters) Continuously Rising?

Small scale bioreactors (< or = 1,000 liters) hold a dominating share of over 63% due to technological advancements. Small scale bioreactors of bench scale (3 L), pilot-scale (50 L and 200 L), enable the successful scale-up of a bio manufacturing process. These are used in early stages of research and bio production of smaller volumes.

Perfusion technology bioreactors allow an increase in scalability of product with size up to 1,000 L working volume. These technologies provide high density viable cell than fed batch technology.

For instance, perfusion technology provide around 5×107 cells/mL cell density as compared to fed-batch that provides 2×107 cells/mL cell density. Technological advancements in the overall biopharma sector have resulted in the growth of this segment.

Why are Biopharmaceutical Companies Key to Market Growth for Perfusion Bioreactors?

Biopharmaceutical companies hold the largest market share of 41%. Perfusion bioreactors are mainly used for cell culture, tissue engineering, and to create media for cells to grow in vitro. This process related to cells and tissues is carried out at biopharmaceutical companies, which is why they lead the end user segment.

Competitive Landscape

The perfusion bioreactors market is greatly consolidated in nature, with the presence of leading players operating in this space. Market players are also engaged in expanding their global and regional presence through acquisitions, expansions, product launches, and improvement of distribution channels.

  • In February, 2021, Thermo Fisher Scientific completed the acquisition of Mesa Biotech, a privately held point-of-care molecular diagnostic company.

Some of the leading companies operating in the market are:

  • Sartorius
  • Cytiva (Danaher Corporation)
  • Cell Culture Company
  • Eppendorf AG
  • Infors HT
  • Synthecon Inc
  • Getinge (Applikon Biotechnology B.V)
  • Thermo Fisher Scientific Inc
  • 3D Biotek LLC

*The list is not exhaustive, and only for representational purposes. Full competitive intelligence available in the report.

Scope of Report



Forecast Period


Historical Data Available for


Market Analysis

USD Billion for Value

Key Regions Covered

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia
  • Oceania
  • The Middle East & Africa

Key Countries Covered

  • US
  • Canada
  • Brazil
  • Mexico
  • Argentina
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Benelux
  • Russia
  • China
  • Japan
  • South Korea
  • India
  • Thailand
  • Indonesia
  • Malaysia
  • Australia
  • New Zealand
  • South Africa
  • Turkey
  • GCC Countries

Key Segments Covered

  • Scale
  • Application
  • End User
  • Region

Key Companies Profiled

  • Sartorius
  • Cytiva (Danaher Corporation)
  • Cell Culture Company
  • Eppendorf AG
  • Infors HT
  • Synthecon Inc
  • Getinge (Applikon Biotechnology B.V)
  • Thermo Fisher Scientific Inc
  • 3D Biotek LLC

Report Coverage

  • Market Forecasts
  • Company Share Analysis
  • Competition Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives

Customization & Pricing

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  • Is this research conducted by Persistence Market Research?

    Yes, the research has been conducted by expert analysts of Persistence Market Research, through a combination of primary and secondary research. To know more about how the research was conducted, you can speak to a research analyst.

  • What research methodology is followed by Persistence Market Research?

    Persistence Market Research follows a methodology that encompasses demand-side assessment of the market and triangulates the same through supply-side analysis. This methodology is based on the use of standard market structure, methods, and definitions.

  • Who are the respondents for primary research?

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  • What are the sources of secondary research?

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Key Market Segment Covered


  • Small Scale Perfusion Bioreactors (< or = 1,000 Liters)
  • Large Scale Perfusion Bioreactors (> 1,000 Liters)


  • Perfusion Bioreactors for R&D
  • Perfusion Bioreactors for GMP

End Users

  • Biopharmaceutical Companies
  • Academic and Research Institutes
  • Contract Research Organization (CRO)
  • Contract Manufacturing Organization (CMO)


  • North America
  • Latin America
  • Europe
  • South Asia
  • East Asia
  • Oceania
  • MEA

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