Perfusion Systems Market Size, Share, and Growth Forecast, 2025 - 2032

Perfusion Systems Market Size and Trends Analysis

The global perfusion systems market size is likely to value US$ 4.64 billion in 2025 and reach US$ 8.4 billion by 2032, growing at a CAGR of 8.9% during the forecast period from 2025 to 2032.

The Perfusion Systems industry is experiencing significant expansion, driven by the rising demand for organ transplantation, increasing prevalence of cardiovascular and respiratory diseases, and technological advancements in perfusion systems.

These systems, critical for maintaining organ viability during transplants and supporting complex surgeries, are gaining traction due to their ability to enhance patient outcomes. The growing adoption of advanced technologies, such as normothermic and hypothermic machine perfusion, along with the expansion of healthcare infrastructure in emerging markets, further fuels market growth.

Key Industry Highlights

• Leading Region: North America, commanding a 40% market share in 2025, driven by robust healthcare infrastructure, high transplant volumes, and the presence of key industry players in the U.S.
• Fastest-Growing Region: Asia Pacific, propelled by increasing healthcare investments, rising chronic disease prevalence, and growing organ transplant awareness in countries such as China and India.
• Investment Plans: In March 2023, LivaNova PLC received U.S. FDA 510(k) clearance for its Essenz Heart-Lung Machine. With FDA approval secured, LivaNova initiated the commercial launch of the Essenz system in the U.S market.
• Dominant Product Type: Cardiopulmonary perfusion systems' share is anticipated to account for over 49% market share in 2025, due to their critical role in cardiac surgeries and high demand for oxygenators.
• Leading End-use: Transplant centers, accounting for nearly 67% of market revenue, are driven by the increasing number of organ transplant procedures globally.

Global Market Attribute

Key Insights	Details
Perfusion Systems Market Size (2025E)	US$4.64 Bn
Market Value Forecast (2032F)	US$8.4 Bn
Projected Growth (CAGR 2025 to 2032)	8.9%
Historical Market Growth (CAGR 2019 to 2024)	7.6%

Market Dynamics

Driver: Rising Demand for Organ Transplantation Fuels Market Growth

The escalating global demand for organ transplantation is a primary driver of the perfusion systems market. With organ shortages persisting worldwide, perfusion systems play a critical role in preserving and assessing donor organs, improving transplant success rates.

According to the Organ Procurement and Transplantation Network (OPTN), over 105,000 individuals were on the U.S. transplant waiting list in 2024, with a new registration every 8 minutes. Globally, according to the Organ Procurement and Transplantation Network (OPTN), which operates under UNOS, organ transplants in the U.S. increased by 5.9% from 2020 to 2021, highlighting the growing need for advanced preservation technologies.

Perfusion systems, particularly normothermic and hypothermic machine perfusion, extend organ viability, enabling the use of marginal or extended-criteria donor organs. In developed markets such as the U.S., the Centers for Medicare & Medicaid Services Organ Transplant Access Model incentivizes hospitals to adopt perfusion technologies, ensuring sustained market growth through 2032.

Restraint: High Costs of Perfusion Systems Limit Adoption in Emerging Markets

The high cost of perfusion systems and associated procedures remains a significant barrier, particularly in emerging economies. In countries such as India and Brazil, where healthcare budgets are constrained, these costs deter adoption. For example, a kidney procurement in the U.S. averages US$36,000, with overhead costs adding to the financial burden.

Additionally, maintenance, single-use circuits, and specialized staffing further escalate expenses. In emerging markets, limited reimbursement policies and a lack of universal protocols for perfusion outcomes exacerbate the challenge. These financial constraints, coupled with regulatory complexities, are expected to hinder market penetration in cost-sensitive regions through 2032.

Opportunity: Advancements in AI-Driven Perfusion Technologies

The integration of artificial intelligence (AI) and real-time analytics into perfusion systems presents significant growth opportunities. AI-driven perfusion platforms enhance organ preservation by providing real-time data on parameters such as oxygen consumption, metabolic activity, and hemodynamics, enabling precise viability assessments.

For instance, AI algorithms have reduced liver discard rates by improving decision-making, as demonstrated by leading U.S. transplant centers in 2024. The adoption of portable, AI-powered perfusion systems, such as LivaNova’s Essenz Patient Monitor, allows for dynamic organ monitoring during transport, expanding donor organ eligibility.

In bio manufacturing, AI enhances automation, improving consistency and scalability in cell perfusion processes. Government and private investments, such as the EU’s funding for medical device innovation, support the development of next-gen portable perfusion platforms.

Companies such as XVIVO Perfusion and TransMedics are leveraging AI to innovate, with products such as the XPS with STEEN solution gaining traction in Europe. These advancements align with global healthcare trends toward precision medicine, offering substantial market expansion potential through 2032.

Category-wise Insights

By Technology

• Hypothermic machine perfusion dominates the market, holding 53% of the revenue share in 2025. Its widespread use in kidney and liver preservation, due to reduced ischemic damage and extended preservation times, makes it a cornerstone in transplant procedures. Systems such as the Kidney Perfusion System bsy Organ Assist are widely adopted in transplant centers for their proven efficacy in reducing delayed graft function.
• Normothermic machine perfusion is rapidly gaining traction due to its ability to maintain organs in near-physiologic conditions, enabling real-time monitoring of organ function. Innovations such as the SherpaPerfusion Cardiac Transport System by Paragonix Technologies enhance heart and lung preservation, supporting higher transplant volumes and improved outcomes.

By Product Type

• Cardiopulmonary perfusion systems lead, capturing over 49% of the market share in 2025. Oxygenators, a critical component, dominate due to their essential role in cardiac surgeries and ECMO procedures. Companies such as Getinge and Terumo Corporation offer advanced oxygenators, meeting the rising demand for cardiothoracic surgeries.
• Ex-vivo organ perfusion systems are experiencing rapid growth, driven by their ability to extend organ viability outside the body. Normothermic ex-vivo systems, such as Organ Ox’s liver perfusion platform, reduce transplant wait times and enable the use of marginal organs, fueling adoption in transplant centers.

By End-use

• Transplant centers hold the largest share, contributing 69% of market revenue in 2025. Their dominance stems from the increasing number of organ transplants globally, with perfusion systems being integral to preserving donor organs. High-volume centers in the U.S. and Europe rely on systems such as TransMedics’ OCS for heart and liver transplants.
• Hospitals are rapidly adopting perfusion systems as perfusion capabilities decentralize. The integration of portable and compact systems, such as LivaNova’s Essenz Heart-Lung Machine, enables hospitals to perform complex surgeries and support ECMO, driving growth in this segment.

Regional Insights

North America Perfusion Systems Market Trends

North America remains the leading region, accounting for approximately 40% of the global perfusion systems market share in 2025. The U.S. is a dominant force driven by its advanced healthcare infrastructure, high volumes of organ transplants, and significant industry presence. Over 41,000 organ transplants were performed in the U.S. in 2021, with perfusion systems playing a critical role, according to OPTN data.

Government initiatives, such as organ donation campaigns, and collaborations, such as Medtronic’s partnership with Spectrum Medical for Quantum Perfusion Systems, enhance market growth. Canada also contributes through its robust healthcare system and increasing adoption of advanced perfusion technologies. The region’s focus on innovation, supported by substantial R&D investments, ensures its leadership through 2032.

Asia Pacific Perfusion Systems Market Trends

The Asia Pacific is the fastest-growing market, driven by rising healthcare investments, the increasing prevalence of cardiovascular and respiratory diseases, and growing awareness of organ transplants. China and India lead, with China’s medical device industry benefiting from government funding for healthcare innovation.

The growing incidences of chronic diseases, such as global chronic Hepatitis B infections in the Asia Pacific, fuel demand for liver transplants and perfusion systems. India’s healthcare reforms and Japan’s Asia Health & Wellbeing Initiatives (AHWIN) promote advanced medical technologies, boosting market expansion. The region’s growing population and improving surgical techniques further accelerate demand through 2032.

Europe Perfusion Systems Market Trends

Europe is the second fastest-growing region, driven by stringent regulatory frameworks, rising health consciousness, and increasing demand for advanced medical devices. Germany, France, and the UK lead, with Germany’s robust healthcare system and R&D investments fostering innovation. The EU’s Medical Device Regulation supports the adoption of perfusion systems, while approvals such as LivaNova’s Essenz system in 2023 enhance market growth.

The rising prevalence of cardiovascular diseases, responsible for 17.9 million deaths annually, drives demand for perfusion systems in surgeries. Europe’s focus on transplant-related research and well-developed healthcare infrastructure ensures steady growth through 2032.

Competitive Landscape

The global perfusion systems market is highly competitive, with key players such as Getinge AB, Medtronic plc, LivaNova PLC, Terumo Corporation, and XVIVO Perfusion AB dominating through innovation and extensive distribution networks. Regional players, such as Organ Assist and Paragonix Technologies, focus on specialized offerings. Companies are investing in AI-driven systems, portable designs, and strategic partnerships to enhance market share, driven by the demand for advanced organ preservation and surgical solutions.

Key Industry Developments

• January 2025: Paragonix Technologies achieved a significant milestone by completing the world’s first-in-human cases utilizing its FDA-cleared KidneyVault Portable Renal Perfusion System. This innovative device is designed for end-to-end hypothermic perfusion of donor kidneys, offering real-time monitoring of critical parameters such as temperature, pressure, and flow during transport.
• February 2023: LivaNova launched the Essenz perfusion system in Europe, integrating advanced data analytics to enhance decision-making during cardiopulmonary bypass procedures. The system includes a next-generation heart-lung machine (HLM) alongside a data-centric patient monitor, designed to enhance patient-tailored care during cardiopulmonary bypass (CPB) procedures.

Companies Covered in Perfusion Systems Market

• Getinge AB
• Medtronic plc
• LivaNova PLC
• Terumo Corporation
• Nipro Corporation
• Fresenius SE & Co. KGaA (XENIOS AG)
• Repligen Corporation
• Spectrum Medical
• Merck KGaA, Harvard Bioscience, Inc.
• Lifeline Scientific
• ALA Scientific Instruments, Inc.
• XVIVO Perfusion AB
• Others