A Detailed Analysis of the Extracellular Matrix Patches Market Based on Increasing Advancements in Regenerative Medicine, New Product Launches and Growing Incidence of Chronic Illnesses.
Report ID: PMRREP33903
Number of Pages: 280
Format: PPT*, PDF, EXCEL
Industry: Healthcare
Published Date: January-2024
The global extracellular matrix patches market is forecast to expand at a CAGR of 7.1% and thereby increase from a value of US$ 26.3 million in 2023 to US$ 42.5 million by the end of 2030.
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Attributes |
Key Insights |
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Extracellular Matrix Patches Market Size (2023E) |
US$ 26.3 Million |
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Projected Market Value (2030F) |
US$ 42.5 Million |
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Global Market Growth Rate (2023 to 2030) |
7.1% CAGR |
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Historical Market Growth Rate (2018 to 2022) |
5.9% CAGR |
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Revenue Share of Top Four Countries (2022E) |
44% |
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Advances in regenerative medicine have made it possible to build customized ECM patches suited to particular medical diseases by providing a more accurate understanding of unique patient profiles. The use of customized therapy improves patient outcomes and therapeutic efficacy. Using stem cells to repair and regenerate tissue is a common practice in regenerative medicine. By combining stem cell research with ECM patches, it is possible to improve their therapeutic potential and progress the creation of more specialized and focused treatments. Complex and personalized ECM patches are created by combining 3D bioprinting technology and regenerative medicine. With this technology, tissues can be precisely built layer by layer, imitating the structure of the extracellular matrix in the body to enhance functionality. New materials with improved biocompatibility and regeneration qualities are developed due to ongoing research in biomaterials science. Biomaterial innovations can enhance the overall effectiveness and integration of extracellular matrix (ECM) patches with the host tissue.
New developments in gene editing methods, such as CRISPR-Cas9, present an opportunity to alter the genetic makeup of ECM patches. This can enhance the patches' general efficacy in tissue healing and optimize them for particular therapeutic uses. Over time, methods for removing cells from tissues while maintaining the structure of the matrix have improved, enabling the extraction of the extracellular matrix from the tissues more effectively. Better decellularization techniques aid in the creation of ECM patches that are more secure and efficient. More funding for regenerative medicine-focused clinical trials and research advances our knowledge of the efficacy and safety of ECM patches. Adoption in clinical practice has increased, and positive clinical study outcomes facilitate regulatory clearances.
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The need for regenerative therapies has grown significantly as a result of the global increase in cardiovascular disorders, such as heart failure and ischemic heart disease. ECM patches are becoming more popular as a treatment for cardiovascular disorders because of their potential to rebuild heart tissue. Diabetes is becoming more and more common, and this is linked to consequences, including tissue damage and chronic sores. ECM patches are becoming increasingly popular in diabetes care because they provide a regenerative approach to treating diabetic ulcers and other related issues. Aging populations and lifestyle factors are contributing to an increase in chronic musculoskeletal disorders like osteoarthritis. ECM patches are a viable treatment option for these long-term conditions by encouraging joint tissue regeneration. Defects and tissue damage are frequent side effects of cancer and its treatments. The regenerative potential of ECM patches in repairing tissues injured by cancer surgery is being investigated, fueling market expansion even more.
In addition, tissue damage can result from long-term inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). ECM patches offer a therapeutic approach for controlling the aftereffects of various inflammatory illnesses by promoting tissue repair. Heart and kidney damage, as well as other cardiovascular issues, are caused by high blood pressure and hypertension. Because ECM patches are regenerative, they can lessen the effects of hypertension. Lung tissue damage is frequently caused by chronic respiratory diseases, such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD). The use of ECM patches in respiratory tissue regeneration to enhance lung function is being investigated.
High Cost of Extracellular Matrix (ECM) Patches to Hinder Market Growth
The process of creating ECM patches necessitates significant financial inputs as well as intensive research and development work. These expenses cover research on the materials' biocompatibility, effectiveness in different medical uses, and adherence to legal requirements. Decellularized tissues are a common source of biological materials used to make ECM patches. These materials can be costly to acquire, process, and purify, which raises the overall cost of producing ECM patches. Producing medical devices like ECM patches requires adhering to regulatory criteria and meeting strict quality assurance standards. The cost burden may increase with the implementation and upkeep of quality control procedures to guarantee efficacy and safety.
Complexity of Tissue Regeneration
The human body's various tissues each have distinct structures and purposes. A thorough grasp of tissue complexity is necessary to design ECM patches that may successfully regenerate particular tissue types, such as cardiac, neural, or musculoskeletal tissues. It can be difficult to guarantee that ECM patches are biocompatible and to control the host's reaction to implants. Distinct tissues may elicit distinct responses from the body's immune system, which could impact the effectiveness of tissue integration and regeneration. The long-term survival of regenerated tissues depends on achieving appropriate vascularization within them. Developing a blood artery network that can sufficiently supply oxygen and nutrients to the regenerated tissue is still a difficult part of tissue regeneration with extracellular matrix patches. It can be difficult for regenerated tissues to integrate seamlessly with the natural tissues surrounding them. Precise engineering matching the original tissue's biomechanical characteristics is necessary for structural and functional integration.
Growing Utilisation in Various Medical Fields
Orthopedic applications, including bone and cartilage healing, have great potential for using ECM patches. They can be applied to sports medicine to repair injured ligaments and tendons, treating typical injuries athletes sustain. ECM patches are appropriate for cardiac applications because they regenerate tissue. They can be used in cardiovascular surgery to restore the myocardium and other injured heart tissues, enhancing cardiac function. The potential of ECM patches in dermatological applications specifically wound healing and skin regeneration, is being investigated. They provide a regenerative method of treating burns, chronic wounds, and other skin abnormalities. In GI Surgery, ECM patches are being researched for potential uses in regenerating and repairing gastrointestinal tissues. They may be used to treat conditions like gastrointestinal fistulas and inflammatory bowel disease.
Moreover, in neurology, ECM patches have the potential to regenerate and repair brain tissue. Applications in the treatment of conditions like neurodegenerative illnesses, traumatic brain injuries, and spinal cord injuries are being investigated. In urology, ECM patches are being explored for potential applications in treating bladder abnormalities and urine incontinence. Their capacity may provide treatment for genitourinary illnesses for regeneration. ECM patches are used in maxillofacial and dental surgery to regenerate the jawbone and periodontal tissues, among other oral tissues. They provide possible remedies for problems including gum disease and tooth decay. ECM patches are being studied for their potential in corneal regeneration and repair in ophthalmic applications. They might aid in the healing of corneal deformities and damage.
What do our Analysts Predict for the Future of the Extracellular Matrix Patches Market?
According to PMR, extracellular matrix (ECM) patches are expected to have a bright future, and they attribute this positive view to several important aspects. With its capacity to promote tissue regeneration and repair, extracellular matrix (ECM) patches are expected to play a key role in regenerative medicine, which is rapidly becoming transformational. This is especially important given the increasing emphasis on creating cutting-edge treatment solutions on a global scale. Innovation in ECM patches is anticipated to be fueled by biomaterials and tissue engineering technology developments, which will increase their usefulness and broaden their scope. The rising incidence of chronic illnesses, which frequently call for sophisticated medical procedures for effective treatment, pushes the market's expansion further. In particular, ECM patches are ideally positioned to meet these objectives in applications involving wound healing.
Additionally, there is a greater need for ECM patches due to the increased number of surgical procedures performed globally. The mix of biocompatibility and functionality offered by these patches is unusual as they are generated from either synthetic materials or natural extracellular matrix. Geographically, emerging economies are predicted to experience market growth due to changing healthcare infrastructure and a growing emphasis on implementing cutting-edge medical solutions. Regenerative medicines like ECM patches are expected to become more widely accepted, opening up new business prospects for industry participants.
Supply-side Dynamics
The US is a leader in developing novel ECM patches with multifunctional properties, sophisticated biomaterials, and fabrication techniques. Companies in this sector that are always pushing the limits of technology are Stryker Medical, Cook Medical, and Aceltis. The US Food and Drug Administration (FDA) establishes strict guidelines for the efficacy and safety of devices, influencing international laws and propelling the creation of reliable ECM patches across borders. Due to its sizable population, high healthcare costs, and strong ecosystem for research and development, the US has a sizable portion of the world market. Europe, Asia-Pacific, and Latin America include established and new players offering a range of approaches and reasonably priced solutions. Companies like Farmaceutica Novo Nordisk (Brazil), Shandong Weigao Group (China), and MiCo Biotech (Switzerland) are essential to producing various ECM patches and meeting local demands.
Additionally, compared to smaller countries, the US naturally experiences a higher overall need for ECM patches due to its population of nearly 330 million. More widespread adoption of ECM patches for a larger range of applications is made possible by well-equipped hospitals, knowledgeable medical staff, and access to various technologies. There is a high burden of age-related problems, surgical procedures, and chronic wounds in the US, all of which could be used for ECM patches and raise demand. The region is large and diversified, with different consumption trends. Rich countries like South Korea and Japan use cutting-edge ECM patches, whereas others rely more on conventional wound healing techniques because of financial limitations.
Which Application Are Expected to Benefit the Most from Revenue Generation?
Extensive Sales for Soft Tissue Repair Category Due to Musculoskeletal Soft Tissue Repair
The application segment is segmented into cardiac repair, dural repair, soft tissue repair, wound healing, vascular repair & reconstruction, and pericardial repair. The soft tissue repair segment is expected to dominate the market. ECM patches heal soft tissues in the musculoskeletal system, including ligaments and tendons. In addition to maintaining structural integrity and encouraging functional recovery following trauma or surgical procedures, they aid in regenerating these tissues. Nonetheless, the extracellular matrix patches market's vascular repair & reconstruction segment is expanding at the quickest rate. Vascular grafts are made using ECM patches to replace or repair damaged blood vessels. These patches offer a framework of support that promotes the growth of new, functioning vascular tissue.
What Raw Material Will Be Targeted the Most Category?
Highest Percent Share Attributed to Porcine Owing to Biological Similarity to Humans
The raw material segment is bifurcated into bovine, porcine, and others. The porcine market segment is the largest for extracellular matrix patches. The composition and structure of porcine tissues are similar to those of human tissues. Because of their biological resemblance, porcine-derived extracellular matrix (ECM) improves compatibility. It lowers the possibility of negative reactions, making them desirable for regenerative medicine applications, such as ECM patches. Nevertheless, the market segment exhibiting the most rapid growth is bovine. Various medical sectors, such as soft tissue repair, orthopedics, and cardiovascular applications, might benefit from the versatility of ECM derived from bovine. Their adaptability drives the demand for bovine basic materials in creating ECM patches for various therapeutic applications.
Why is North America Emerging as a Dominating Region?
Increasing Patient Demand for Advanced Treatments to Drive Market Growth
North American patients frequently express a preference for advanced medical treatment that makes use of the most recent developments in science and technology. Because ECM patches are a component of regenerative medicine, they support this need for cutting-edge and novel treatments. Compared to conventional surgical techniques, ECM patches provide a minimally invasive tissue regeneration and repair approach. Patients interested in less invasive procedures are more likely to choose therapies that support their body's natural healing mechanisms. Treatments customized to meet each patient's needs are becoming more and more common in personalized medicine. ECM patches fit in well with this customized approach to therapy because they may be customized based on the needs of individual patients. Long recovery times are a common side effect of traditional surgical treatments. Due to their potential for quicker recovery and less downtime, regenerative characteristics make ECM patches appealing to patients looking for less intrusive and quicker treatment choices.
What Opportunities Lie in Asia Pacific for Manufacturers?
Increasing Medical Tourism to Advance Market Growth
Asia Pacific nations are renowned for offering affordable healthcare options, especially those in Southeast Asia. Travelers seeking cutting-edge and reasonably priced regenerative medicines like ECM patches may receive treatment in this area. The Asia-Pacific region has made considerable investments in creating top-notch medical infrastructure. International patients looking for regeneration treatments like ECM patches are drawn to the area by the existence of advanced, well-equipped medical facilities. Asia-Pacific nations are home to knowledgeable and proficient medical experts with various specializations, including regenerative medicine. The presence of skilled healthcare specialists further enhances the region's appeal to medical tourists seeking ECM patch therapy. A broad range of healthcare services that meet various medical needs are offered throughout Asia. Patients looking for specialized treatments are drawn to the availability of complete healthcare services, which include regenerative therapies like ECM patches.
Prominent organizations, including Cook Group and Boston Scientific Corporation, are at the vanguard of this sector; Cook makes use of its biologics experience with products such as Bio-Oss Collagen, a xenogeneic (produced from animals) bone substitute that includes elements of the extracellular matrix. Cook funds the creation of synthetic substitutes like Vitracoll, a bioresorbable collagen-based membrane utilized in various surgical techniques. Cook's FortaTM covers, which combine a synthetic scaffold and a bi-layered collagen membrane for hernia repair, are an example of hybrid extra-cardiac mesh (ECM) patches. These cover combining the benefits of both approaches. Cook capitalizes on its significant market share in orthopedics by providing ECM patches for bone and cartilage restoration, tendon and ligament augmentation, and spinal fusion surgeries. Cook's ECM patches are used in wound healing, breast reconstruction, and hernia repair in addition to orthopedics. Cook looks into prospects with ECM patches that address particular gynecology, urology, and cardiovascular surgery needs.
Boston Scientific creates its ECM patches with laparoscopic and other minimally invasive procedures in mind, facilitating a quicker recovery and less discomfort for patients. Their emphasis corresponds with the trend in several medical specialties towards minimally invasive procedures. Boston Scientific creates a more complete surgical solution by incorporating ECM patches into its current product line for particular operations. This expands their current distribution networks and well-established reputation across various medical disciplines. Boston Scientific partners with smaller businesses and research institutes to gain access to cutting-edge ECM technology and broaden their product offerings. In 2019, they acquired Humacyte, a regenerative medicine startup creating acellular human-derived extracellular matrix products, to gain entry into a potential future growth market.
New Product Launch
Sanara MedTech Inc. introduced two cutting-edge extracellular matrix products from Cook Biotech Inc. in November 2021: FORTIFY FLOWABLE Extracellular Matrix and FORTIFY TRG, a tissue repair graft. These product introductions drive the market's expansion.
Market Impact: Sanara's entry into the ECM market with these two new products gave surgeons and other healthcare providers more alternatives, which could result in a rise in the use of ECM technology. By diversifying, Sanara also increased its market share in the expanding ECM patches industry. The ECM industry will get more competitive due to Sanara MedTech's new product launches. This may spur additional innovation and new and established companies' creation of fresh, enhanced ECM products. To compete with Sanara MedTech and provide alternatives, other businesses might be incentivized to engage in research and development in this area.
Terumo Corporation announced the start of the worldwide surgical graft research PANTHER in September 2021. This retrospective and prospective study examines cardiovascular patches and a range of knitted and woven surgical grafts.
Market Impact: PANTHER is a multi-arm, large-scale study that will take place throughout many years and geographies and is expected to produce useful data regarding the long-term performance of multiple Terumo grafts and patches. Clinical decision-making can be informed, and this greater data transparency can bolster surgeon confidence. Terumo can produce more robust and efficient grafts and patches by utilizing real-world performance data to inform the development of new products and the optimization of current ones.
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Details |
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Forecast Period |
2023 to 2030 |
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Historical Data Available for |
2018 to 2022 |
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Market Analysis |
US$ Million for Value |
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Key Regions Covered |
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Key Countries Covered |
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Key Market Segments Covered |
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Key Companies Profiled |
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Report Coverage |
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Customization & Pricing |
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