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A Detailed Analysis of the Market for DNA Synthesis Based on Expanding Applications in Synthetic Biology, Personalized Medicine, And Biotechnology
The global DNA synthesis market is forecast to expand at a CAGR of 14.5% and thereby increase from a value of US$3.3 Bn in 2023, to US$ 8.5 Bn by the end of 2030.
DNA Synthesis Market Size (2023E)
Projected Market Value (2030F)
Global Market Growth Rate (CAGR 2023 to 2030)
Historical Market Growth Rate (CAGR 2018 to 2022)
A crucial procedure in biotechnology and genetic engineering, DNA synthesis pertains to the manipulation of DNA strands within laboratory settings. This complex process entails the chemical synthesis of nucleotide sequences in a manner that emulates the organic DNA synthesis that takes place in living organisms. To compose nucleotides in precise sequences, scientists utilize a variety of techniques, including solid-phase synthesis. This permits the fabrication of customized DNA fragments, which find extensive application in the fields of medicine, biotechnology, and research. The DNA synthesis market comprises the necessary instruments, reagents, and services that are integral to the field of synthetic biology. Its operations support the progress made in domains such as personalized medicine, gene editing, and synthetic biology.
The worldwide market for DNA synthesis is driven by a multitude of contributing factors. The market expands due to the rising demand for synthetic genes utilized in genetic engineering, vaccine development, and therapeutic applications. Increased adoption of gene synthesis is facilitated by technological advancements, including high-throughput techniques and decreased synthesis costs. The market is further propelled by the increasing incidence of genetic disorders and the proliferation of personalized medicine initiatives. Moreover, innovation is expedited through the collaborative endeavours of academic research institutions and industry participants. The expanding utilization of synthetic DNA in various sectors such as agriculture, biopharmaceuticals, and the environment further stimulates the market's expansion, thereby establishing a vibrant international environment for DNA synthesis technologies.
Growing Demand for Application of Synthetic Genes in Therapeutic Settings
A significant factor propelling the worldwide DNA synthesis market is the increasing need for synthetic genes to be utilized in therapeutic contexts, specifically within the domain of gene therapy. To prevent or treat maladies, gene therapy entails the introduction, modification, or replacement of genetic material within a patient's cells. With the advancement of knowledge regarding the genetic underpinnings of numerous disorders, gene therapy has surfaced as a potentially fruitful avenue for the creation of individualized and targeted therapies. The increased demand for custom-designed synthetic genes, which are essential for modulating and controlling gene expression, has been fuelled by this paradigm shift in healthcare.
The substantial increase in the need for synthetic genes can be ascribed to the swift progressions in precision medicine and the growing acknowledgment of gene therapy's capacity to treat genetic disorders that were previously incurable. The utilization of CRISPR-Cas9 and other gene editing technologies has significantly enhanced the capacity to modify and engineer DNA with unparalleled precision and efficiency. As a consequence, novel therapeutic approaches that specifically target genetic anomalies at the molecular level have been made possible. Synthetic genes are of utmost importance in these therapeutic interventions as they provide the fundamental components necessary to construct therapeutic nucleic acids, including mRNA, siRNA, and CRISPR guides. By customizing these synthetic genes, it becomes possible for clinicians and researchers to develop therapeutic nucleic acids that are precise to the genetic mutations or dysregulations that are the cause of a patient's condition.
Challenges in Ethics and Regulations Arising from the Manipulation of Genetic Material
The global DNA synthesis market is substantially hindered by the ethical and regulatory complexities that arise from the manipulation of genetic material. The escalating capabilities of DNA synthesis technologies have brought to the forefront concerns regarding the ethical ramifications associated with the production, alteration, and manipulation of genetic information. The ethical quandaries that arise from the potential for synthetic biology to be misapplied or produce unintended outcomes, such as the modification of human germline cells or the development of artificial life forms, demand meticulous deliberation.
The inadequate adaptation of regulatory frameworks to the swift advancements in DNA synthesis technologies results in regulatory uncertainties and postponements about the approval of specific applications. The task of reconciling the imperative for innovation with ethical deliberations and possible hazards presents policymakers and regulatory organizations across the globe with formidable obstacles.
The Inherent Costs and Complexities Associated with Conducting Comprehensive Endeavours
A significant obstacle for the worldwide DNA synthesis industry is the expense and intricacy that are intrinsic to conducting extensive, high-throughput DNA synthesis. With the increasing demand for synthetic genomes and customized DNA sequences, synthesis methods that are both efficient and scalable are becoming increasingly crucial. Conventional methods of DNA synthesis, including solid-phase synthesis, are resource-intensive and time-consuming, which restricts their applicability to large-scale manufacturing.
Furthermore, the escalating intricacy of synthetic biology applications—such as the construction of intricate genetic circuits and gene editing—requires advanced DNA synthesis technologies with high throughput. The advancement of innovative and cost-effective synthesis techniques, including enzymatic and microarray-based methods, encounters obstacles to scalability.
One of the factors propelling the worldwide DNA synthesis market is the expanding utilization of synthetic biology in industrial sectors, which provides industries with revolutionary solutions. Synthetic biology encompasses the conceptualization and fabrication of novel biological components, apparatus, and systems, as well as the functional redesign of established, natural biological systems. Synthetic biology and DNA synthesis are being utilized in the industrial sector to manipulate microorganisms to generate bio-based materials, compounds, and biofuels. This phenomenon offers a substantial opportunity for the DNA synthesis industry to supply customized genetic constructs, thereby facilitating the enhancement of microorganisms' efficiency and sustainability in industrial operations.
The increasing prevalence of sustainable and environmentally conscious practices has expedited the integration of synthetic biology into industrial environments, thereby generating prospects for DNA synthesis technologies to aid in the advancement of biomanufacturing procedures. The efficient conversion of renewable resources into valuable products using engineered microorganisms can reduce dependence on conventional, resource-intensive manufacturing techniques. This not only corresponds with the worldwide movement towards sustainable practices but also provides economic advantages through the establishment of production processes that are more streamlined and economical.
With various sectors striving to minimize their ecological footprint and embrace more sustainable methods, such as pharmaceuticals, chemicals, and agriculture, the DNA synthesis industry has the potential to benefit from the growing need for customized genetic constructs that facilitate accurate regulation of microbial function and behaviour in industrial settings. The intersection of synthetic biology and industry offers a potentially fruitful pathway for DNA synthesis technologies to significantly influence the trajectory of environmentally responsible biomanufacturing worldwide.
A convergence of factors emphasizing the critical importance of synthetic biology and genetic engineering across industries is propelling the global DNA synthesis market toward substantial expansion. Advancements in gene therapy, the expansion of personalized medicine, and the increasing demand for custom-designed genetic material are all significant factors driving market expansion. The market is being propelled forward due to the rising prevalence of genetic disorders and the pursuit of targeted therapeutic solutions, which are driving demand for synthetic genes and custom oligonucleotides. The increasing understanding of the genetic foundations of diseases necessitates the development of precise and customizable DNA synthesis techniques to advance therapeutics.
Notable are the synergies that exist between gene therapy and DNA synthesis, given that the latter is the foundation for the production of therapeutic nucleic acids including mRNA and CRISPR guides. Sustainability, precision medicine, and industrial applications are factors that contribute to the DNA synthesis market's bright future. Gene synthesis technologies are anticipated to have a significant impact on the manufacturing of bio-based substances, compounds, and biofuels, which is consistent with the worldwide trend toward environmentally sustainable practices.
The proliferation of DNA synthesis in diverse industrial sectors, such as environmental and agricultural, exemplifies the market's adaptability and capacity for far-reaching consequences. The development of high-throughput synthesis methods, cost-reduction strategies, and ongoing innovation in gene editing technologies are significant trends influencing the market's trajectory. The advent of CRISPR-Cas9 and other gene editing tools has brought about a paradigm shift in the accuracy and productivity of genetic manipulation, thereby broadening the scope of DNA synthesis applications.
Prominent companies including Integrated DNA Technologies, Thermo Fisher Scientific, and GenScript Biotech Corporation are present in the global DNA synthesis market. These market leaders are spearheading the development of state-of-the-art DNA synthesis technologies, which propels the expansion of the industry. The United States is a leading country in terms of market adoption, with the biopharmaceutical industry making extensive use of DNA synthesis for drug discovery. In addition, China is positioning itself as a significant participant in the field, as evidenced by the increasing attention it pays to genomics and biotechnology, as firms such as BGI Genomics demonstrate. European nations, with particular emphasis on Germany and the United Kingdom, are proactively integrating DNA synthesis into their scientific investigations and practical sectors.
The DNA synthesis market is being influenced by market leaders through their efforts to promote technological progress, diversify their product lines, and establish strategic alliances. A key participant, Thermo Fisher Scientific, introduces novel synthesis platforms regularly, thereby improving the scalability and effectiveness of DNA production. Gene synthesis is being transformed by the one-of-a-kind silicon-based DNA synthesis platform developed by Twist Bioscience, which enables the economical and timely production of customized DNA sequences.
A pioneer in therapeutic applications and customized gene synthesis services, GenScript Biotech Corporation is significantly impacting the industry by implementing CRISPR technology and custom gene synthesis services. The dedication of Integrated DNA Technologies to providing synthetic DNA of superior quality has solidified its position as a reputable supplier within the industry. Using mergers and acquisitions, these dominant actors not only advance technological capabilities but also drive market consolidation, thereby strengthening their positions.
What Service Type Will Be Targeted the Most for Installations?
Custom Oligonucleotides Represent the Largest Segment
It is anticipated that the custom oligonucleotide segment will hold the most substantial market share in the DNA synthesis industry. Custom oligonucleotides are extensively employed in a multitude of applications, encompassing DNA sequencing, PCR, and gene synthesis. Their adaptable and specific characteristics render them a multifunctional instrument in the realm of molecular biology research and diagnostics. For specific research purposes, the demand for precise and tailored sequences is what propels the custom oligonucleotide segment to the forefront. The sector exhibiting the most rapid expansion is the gene library division.
Gene libraries, comprising a compilation of genetic sequences, are proving to be ever more indispensable in the fields of functional genomics, high-throughput screening, and drug discovery. The increasing focus on comprehending intricate genetic interactions and discovering new therapeutic targets drives the rapid uptake of gene libraries, establishing this sector as the most rapidly expanding within the DNA synthesis industry. The exponential expansion of genomics research and drug development endeavours plays a significant role in the rapid development of gene libraries, establishing them as a pivotal catalyst for the progression of DNA synthesis in the future.
Which sales-focused application to prioritize?
R&D Dominates Market Share via Deep Integration in Genetics and Molecular Biology
It is expected that the "Research and Development" sector will hold the most significant portion of the DNA synthesis market. This particular segment comprises an extensive range of applications spanning multiple scientific fields, such as genetics, molecular biology, and biotechnology. Research and development has a high demand for DNA synthesis instruments and services, given their critical role in driving scientific progress and fostering innovation. Pharmaceuticals is the sector anticipated to experience the most rapid expansion. The increasing prominence of personalized medicine and gene therapy has generated a substantial and expanding need for DNA synthesis in the field of therapeutics. Increasing emphasis on precision medicine, the development of custom genes for targeted treatments, and advancements in gene editing technologies all contribute to the therapeutics segment of the DNA synthesis market expanding at a rapid rate. Given its capacity to tackle genetic disorders and create innovative therapeutic interventions, the therapeutics sector emerges as a significant catalyst for expansion within the dynamic domain of DNA synthesis.
Who Will Benefit Most from Revenue Generation Among End Users?
Biopharmaceutical firms to lead market with accelerated drug discovery
It is anticipated that the segment known as "Biopharmaceutical Companies" will hold the most substantial portion of the DNA synthesis market. DNA synthesis is a widely employed technique by biopharmaceutical companies to facilitate drug discovery, development, and biological production. This segment's substantial market share is a result of the expanding emphasis on the development of novel therapeutics and the incorporation of genomics into drug research. It is envisaged that the "Contract Research Organizations (CROs)" segment will experience the most rapid growth. As a result of the biopharmaceutical industry outsourcing a substantial portion of its research and development to CROs, it is anticipated that the demand for DNA synthesis services will increase. Critical success factors (CROs) are their ability to provide specialized and cost-effective DNA synthesis solutions, which propels their exponential expansion in the ever-changing DNA synthesis industry. Given their ability to address the varied demands of the biopharmaceutical industry, CROs are well-positioned to experience accelerated growth due to their adaptability and specialized knowledge.
North America Dominates with Significant Investments by Biopharma Companies, and Research Institutions
It is anticipated that North America will hold the largest market share of the worldwide DNA synthesis industry. This is the result of a confluence of factors that collectively account for the region's industry dominance. A significant catalyst is the existence of a firmly established biotechnology and pharmaceutical industry, with the US being a prime example. Numerous biopharmaceutical companies and research institutions with substantial investments in DNA synthesis for drug discovery, genetic research, and therapeutic development are based in this region.
Furthermore, North America is endowed with a resilient ecosystem that promotes technological progress and ingenuity in the field of synthetic biology. The region's dominance is further strengthened by the presence of advanced research facilities and infrastructure, as well as the concentration of key market participants. North America's leadership position in the global DNA synthesis market can be attributed to several factors, including the substantial investments in research and development, the favorable regulatory frameworks in place, and the high rate of adoption of advanced technologies.
Growth of Biotech Industries Across Australia, and Singapore Carve Opportunities in South Asia, and the Pacific
It is anticipated that the South Asia, and the Pacific region will witness the most rapid expansion of the worldwide DNA synthesis market. A confluence of factors contributes to the region's growing appeal as a location for DNA synthesis applications. The expanding healthcare and biotechnology industries in nations such as Australia, Singapore, and India are driving an increasing need for DNA synthesis for diagnostic, therapeutic, and agricultural biotechnology applications. Furthermore, the increasing emphasis on personalized healthcare, genomics, and precision medicine in the region is propelling the demand for customized DNA synthesis solutions.
Increasing investments in research and development and the adoption of cutting-edge technologies are factors driving the rapid expansion of the DNA synthesis market in South Asia, and the Pacific. Furthermore, the region's burgeoning biotechnology landscape, collaborative partnerships with multinational biotechnology corporations, and favorable government initiatives collectively establish it as a prime location for market growth. Given the strong economic expansion observed in South Asia, and the Pacific and the increasing prominence of the biotechnology sector, it is anticipated that the DNA synthesis market will thrive, positioning this region as the most rapidly developing in this ever-evolving industry.
Prominent entities in the worldwide DNA synthesis industry, such as Integrated DNA Technologies (IDT), Thermo Fisher Scientific, GenScript Biotech Corporation, and Twist Bioscience, utilize a variety of strategic initiatives to maintain and increase their market dominance. A prominent participant in the industry, Thermo Fisher Scientific prioritizes innovation and a varied product portfolio. The organization consistently allocates resources toward research and development to introduce cutting-edge DNA synthesis technologies that effectively cater to the changing demands of biopharmaceutical companies, researchers, and other relevant stakeholders.
The acquisitions made by Thermo Fisher Scientific, including Life Technologies, have significantly enhanced the company's market standing and facilitated the provision of all-encompassing solutions throughout the genomics workflow. GenScript Biotech Corporation, an organization renowned for its proficiency in gene synthesis, implements a customer-centric strategy. The organization offers customized gene editing tools, CRISPR constructs, and gene synthesis services. Because of its focus on customization and accuracy, GenScript is the preferred option for scientists in pursuit of superior synthetic genes.
Further, to broaden its scope and provide integrated solutions for genetic research and therapeutic development, the organization actively pursues collaborations and partnerships. To achieve maximum market share, these dominant actors prioritize innovation, customer-centric approaches, and strategic collaborations. Through a consistent commitment to technological innovation, portfolio diversification, and adaptability to the ever-changing demands of the biotechnology and pharmaceutical industries, these businesses establish themselves as frontrunners in the dynamic and fiercely competitive DNA synthesis market.
2023 to 2030
Historical Data Available for
2018 to 2022
US$ Million for Value
Key Regions Covered
Key Countries Covered
Key Market Segments Covered
Key Companies Profiled
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The market is anticipated to grow at a cagr of 14.5%% during the projected period.
The DNA synthesis market was valued at US$3.3 billion in 2023.
The US held the largest market share in 2023.
Some of the prominent players in the market are Brooks Automation, Inc. (Genewiz), Boster Biological Technology, Proteogenix, and Biomatik.
The contract research organizations segment is expected to experience the highest CAGR during the forecast period.