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Guided Bone Regeneration Market

Market Study on Guided Bone Regeneration: Bone Graft Substitutes Accounts for Over Two-third Market Share

Guided Bone Regeneration Segmentation By Material - Bone Graft Substitutes ( Allograft, Xenograft, Synthetic Bone Graft ), Barrier Membranes ( Expanded Polytetrafluoroethylene (e-PTFE), High-density Polytetrafluoroethylene (d-PTFE), Titanium Mesh and Titanium-reinforced PTFE).

Guided Bone Regeneration Market Outlook (2023­­­­­­­­­­­ to ­­­2033)

Revenue from the global guided bone regeneration market reached US$ 727.7 million in 2022, with the market predicted to evolve at a CAGR of 4.6% to reach a valuation of US$ 1.2 billion by the end of 2033. According to Persistence Market Research, bone graft substitutes accounted for a market value of US$ 514 million in 2022.

The market for guided bone regeneration recorded a CAGR of 3.1% over the past 5 years (2017 to 2022) and accounted for 14.3% share of the global bone regeneration market in 2022.

Due to the rising prevalence of oral diseases, the use of bone graft substitutes has increased in recent years in the field of dentistry.

  • As per findings from the WHO Global Oral Health Status Report, oral diseases affected around 3.5 billion people all over the world in 2022. It is due to improper hygiene and diet that the prevalence of oral diseases has increased significantly.

Since guided bone regeneration is a technique used in the field of dentistry for hard tissue reconstruction, this rise in oral diseases will increase the use of bone substitutes even in the future and would have a positive impact on the growth of the market. Apart from this, technological advancements in relation to this market have been another driving factor. Synthetic bone substitutes have gradually taken the role of natural bone grafts in the industry as a result of ongoing technological improvements. The development of hybrid grafts comprises the utilization of osteogenic cells that can trigger bone regeneration and growth factors, and this is something that is the future of dental bone grafting and dental implants.

Companies have incorporated their own technology to provide improved and innovative products.

  • For instance, the GLYMATRIX® Core Technology that drives OSSIX solutions for guided bone regeneration (GBR), and guided tissue regeneration (GTR) imitates the body's normal collagen cycle, a process known as glycation and collagen membranes from Biotech Dental use cutting-edge technology and innovation to serve the mechanical, physical barrier, and preventive functions in GBR.

This points to the increasing use of guided bone regeneration materials, thereby driving the market in a positive manner.

It has been observed that, with the increasing number of dental disorders, the number of dental practitioners is also increasing. This growing number of dental practitioners is leading to an increase in the use of guided bone regeneration in implantology, periodontology, and surgery. All in all, the increasing number of dental practitioners is supporting the growing demand for oral care and related products.

The growth in the number of such application areas is significantly linked to the increasing number of guided bone regeneration materials. The clinical use of GBR membranes has grown in recent years. The principal application of GBR membranes has been in bone augmentation surgery. GBR membranes have recently been employed in periodontal flap surgery or the removal of the third molar in the mandible. Additionally, GBR membranes are utilized to cure peri-implant bone loss.

Guided Bone Regeneration Market Size (2023)

US$ 755.6 Million

Projected Market Value (2033)

US$ 1.2 Billion

Global Market Growth Rate (2023–2033 )

4.6% CAGR

Market Share of Top 5 Countries


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Why is Demand for Guided Bone Regeneration Growing?

“Increased Adoption of Innovative Products in the Market”

Guided bone regeneration includes a variety of materials. Researchers are working on material development to increase their efficacy and mode of action. Different bone graft substitutes from bovine, porcine, and other sources that have been derived from making xenograft and allograft are being highly adopted in bone graft substitutes. The use of synthetic materials gave rise to alloplastic grafting material, which is synthetically derived or made from natural materials.

Similarly, the emergence of the vegan sector has forced manufacturers to concentrate on the creation of plant-based substitutes for xenograft and allograft, which is important due to the growing vegan population as well as religious considerations. Phycografts are the name for these plant-based grafts.

  • For instance, Osstem Implants introduced A-Oss, which creates 3D microporous structures strikingly resembling those of human bones, in 2022, allowing it to reach its full biocompatible and osteoconductive potential.

In addition, increasing investments in the dentistry field of medical science will present lucrative opportunities for market players.

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Are There any Barriers That Can Adversely Affect Market Growth?

Clinical Complications in Guided Bone Regeneration Procedures

The uncontrolled duration of barrier function (resorption period can range from four to sixteen weeks) and the requirement for membrane-supporting material to prevent membrane collapse are some disadvantages of resorbable membranes.

In some circumstances, the resorption process can obstruct the healing of wounds and may have a detrimental effect on bone regeneration. When inserted into a living body, non-resorbable membranes do not experience the same enzymatic breakdown as resorbable membranes. As such, they need to be removed via a second surgical procedure. The regeneration process may completely fail as a result of these membranes being exposed.

Earlier, e-PTFE membranes were able to detect the presence of potentially pathogenic bacteria in the outer as well as in the inner surfaces of membranes that became exposed. Efforts should be made to avoid membrane exposure and the surgical technique should achieve primary membrane coverage to be simple, effective, and stable. Hence, there is a scope for development to address these clinical complications and also reduce patient morbidity and expenses.

Also, higher prices associated with the materials that are used in guided bone regeneration is another factor that can restrain the growth of this market.

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Country-wise Insights

What Makes the United States a Leading Market for Guided Bone Regeneration?

“Increase in Number of Dental Practitioners in the Country”

The United States accounted for 92.6% share of the North American market in 2022, and a similar trend is expected over the forecast period as well.

  • As per findings by the Health Policy Institute, the American Dental Association reported that the number of dentists in the U.S. remains stable at around 60.8 dentists per 100,000 in 2021. This number is expected to increase to 67 dentists per 100,000 population by 2025.

A high elderly population base, established market leaders, and increased investments by market leaders across the industry are broadening the portfolio and driving the guided bone regeneration industry's overall expansion across the country. Leaders in biomaterial manufacturing are also aiming to commercialize guided bone regeneration materials, creating attractive potential for market growth over the course of the forecast period.

Will Germany be a Lucrative Market for Guided Bone Regeneration Providers?

“Increasing Prevalence of Periodontal Diseases”

Germany accounted for 22.5% share of the European market in 2022 and was valued at US$ 42.9 million.

  • According to data from the Fifth German Oral Health Study published in BMC Oral Health in 2014, periodontal diseases were quite high among the German population.

These diseases with a higher level of severity are linked with the increase in dental implant procedures, which, in turn, will have a positive impact on the market in Germany.

Why is China Emerging as a Huge Market for Guided Bone Regeneration?

“Substantial Rise in Geriatric Population”

China held a significant market share of 48.2% in East Asia in 2022. It is set to exhibit growth at 5.4% CAGR throughout the forecast period.

  • Around 254 million Chinese citizens were 60 years of age or older, and 176 million were 65 years of age or older, according to data from WHO in 2019. As per the same report, this figure would rise to 402 million in the case of people who are 60 and above age group, by the year 2040.

With the increasing number of dental diseases and disorders among the aging population, the demand for guided bone regeneration materials in the country is expected to increase substantially over the coming years.

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Category-wise Insights

Which Guided Bone Regeneration Material is Exhibiting High Usage?

“High Availability of Bone Graft Substitutes”

Bone graft substitutes accounted for 70.7% share of the global market in 2022.

When it comes to the different materials of guided bone regeneration, allografts, xenografts, and synthetic bone grafts are highly recommended by dental practitioners as compared to various barrier membranes. Bone graft substitutes provide higher mechanical strength and are therefore highly efficient when it comes to guided bone regeneration.

High segment growth is because the number of bone graft substitutes available in the market is significantly higher than barrier membranes.

Which Application is Largely in Focus for Market Players?

“Rise in Number of Dental Implant Procedures”

The implantology segment held 39.5% share of the total market in 2022. The segment is expected to move ahead at a CAGR of 4.8% over the period of 2023 to 2033.

Since the guided bone regeneration procedure is usually carried out to reconstruct small defects around dental implants, as compared to other applications, implantology is a prominent segment in this market. Dental implants are evolving into the go-to procedure to restore lost teeth and enhance patients' quality of life.

Competitive Landscape

Key market players are significantly involved in new product launches and expansion in emerging markets. Some companies are involved in partnerships for technological advancements, focussing on research & development activities and acquiring small companies for business growth.

For instance:

  • In December 2019, Geistlich Biomaterials released Geistlich vallomix, which was the first xenogeneic or allogeneic validated bone substitute. It easily co-packages two of the bone substitutes, such as Vallos, which is a demineralized cortical allograft, and Geistlich Bio-Oss®, which is the top xenogeneic bone substitute.
  • In September 2019, Zimmer Biomet and Align Technology, a manufacturer of several 3D oral scanning devices for digital restorative dentistry, struck a global distribution partnership.

Similarly, recent developments have been tracked by the team at Persistence Market Research related to companies in the guided bone regeneration space, which are available in the full report.

Guided Bone Regeneration Industry Report Scope



Forecast Period

2023 to 2033

Historical Data Available for

2017 to 2022

Market Analysis

  • USD Million for Value
  • Volume (‘000 Units)

Key Countries Covered

  • U.S.
  • Canada
  • Brazil
  • Mexico
  • Argentina
  • Germany
  • Italy
  • France
  • U.K.
  • Spain
  • Russia
  • Nordic Countries
  • India
  • Indonesia
  • Malaysia
  • Thailand
  • China
  • Japan
  • South Korea
  • Australia
  • New Zealand
  • GCC Countries
  • Turkey
  • Northern Africa
  • South Africa

Key Market Segments Covered

  • Material
  • Application
  • End User
  • Region

Key Companies Profiled

  • Baxter International Inc.
  • Medtronic
  • Stryker Corp.
  • Integra LifeSciences
  • Zimmer Biomet Holdings
  • Dentsply Sirona
  • botiss biomaterials GmbH
  • Geistlich Pharma AG
  • Biotech Dental
  • Dentegris GmbH
  • GENOSS Co., Ltd.
  • Osstem Implant

Report Coverage

  • Market Forecast
  • Competition Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives

Customization & Pricing

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Guided Bone Regeneration Industry Research Segmentation

By Material:

  • Bone Graft Substitutes
    • Allograft
    • Xenograft
    • Synthetic Bone Graft
    • Others
  • Barrier Membranes
    • Expanded Polytetrafluoroethylene (e-PTFE)
    • High-density Polytetrafluoroethylene (d-PTFE)
    • Titanium Mesh and Titanium-reinforced PTFE

By Application:

  • Implantology
  • Periodontology
  • Oral and Maxillofacial Surgery
  • Others

By End User:

  • Hospitals
  • Dental Clinics
  • Academic & Research Centers
  • Ambulatory Surgical Centers

By Region:

  • North America
  • Latin America
  • Europe
  • South Asia
  • East Asia
  • Oceania
  • Middle East & Africa (MEA)

- Companies Covered in This Report -

  • Baxter International Inc.
  • Medtronic
  • Stryker Corp.
  • Integra LifeSciences
  • Zimmer Biomet Holdings
  • Dentsply Sirona
  • botiss biomaterials GmbH
  • Geistlich Pharma AG
  • Biotech Dental
  • Dentegris GmbH
  • GENOSS Co.,Ltd.
  • Osstem Implant

- Frequently Asked Questions -

The global guided bone regeneration market was valued at US$ 727.7 million in 2022.

The market for guided bone regeneration is expected to reach US$ 1.2 billion by 2033.

Demand for guided bone regeneration increased at 3.1% CAGR from 2017 to 2022.

Between 2023 and 2033, the market is forecasted to expand at a CAGR of 4.6%.

Bone graft substitutes are predicted to account for 70.9% market share by 2023.

The U.S., China, Germany, India, and the U.K. currently account for 57.6% market share.

The U.S. accounted for 92.6% share of the North American market in 2022.

The European market is predicted to expand at 4% CAGR over the forecast period.

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