Global Market Study on Freeze and Thaw Systems: What’s Stored for the Future of Medicine?


Freeze And Thaw Systems  Market
  • Published On : Aug-2019 |
  • Pages : 221 Pages |
  • Format :

Freeze and Thaw Systems Market Report: Introduction 

The latest research study performed by Persistence Market Research (PMR) analyzes the historical and the current scenario of the ‘Global Freeze and Thaw Systems Market’ to accurately estimate the future opportunistic development of the market. The report includes detailed information pertaining to the pivotal growth determinants, trends and restraints that are shaping the growth dynamics of the freeze and thaw systems market to identify the lucrativeness of the business for market players. The study also offers incisive information about how the freeze and thaw systems market will grow and gain momentum during the projection period 2019-2029. 

The report offers incisive dynamics related to the various aspects and nuances of the freeze and thaw systems market to aid the market enthusiasts make winning strategies. PMR’s report also sheds light on the key changes that are highly likely to shape the freeze and thaw systems market during the forecast period. It includes a key indicator assessment to highlight how the market is developing and what are the existing growth prospects of the freeze and thaw systems market and forecast statistics related to the progress of the market in terms of volume (units) and value (US$ Mn).

The report covers a detailed taxonomy of the freeze and thaw systems market and valuable insights on market competitive landscape. The research also covers company profiles of the leading as well as established stakeholders that are vying to squeeze higher gains and solidify their position in the freeze and thaw systems market. Numerous development and winning strategies formed and leveraged by the leading market players have been presented in detail in the study report.

Freeze and Thaw Systems Market - Segmentation

PMR’s research study gauges the freeze and thaw systems market on the basis of product, application, end user and region. The study offers information about the rapidly altering market dynamics and the various determinant factors related to segments that are shaping the progress prospects of the freeze and thaw systems market.

Product

Application

End Use

Region

Freeze-Thaw Modular Platforms

  • Lab Scale
  • Small/Pilot Scale
  • Large Scale

R&D

Academic & Research Insititutes

North America

Controlled  Rate Chambers

Pre-Clinical & Clinical

Pharmaceutical & Biotechnology Companies

Latin America

Single-Use Bags

Commercial

Contract Research Organizations

Europe

Shippers

Contract Manufacturing Organizations

East Asia

South Asia

Oceania

MEA

What are the Salient Questions Answered in PMR’s Report on Freeze and Thaw Systems Market? 

The report offers comprehensive information about the freeze and thaw systems market on the basis of detailed research pertaining to the macro and microeconomic factors that are playing a pivotal role in shaping the growth potential of the market. The study answers to diverse queries for the presently operating market players and the companies that are eying to penetrate in the freeze and thaw systems market, to assist them strategize right approaches and take business-driving decisions. 

  • Which freeze and thaw systems will promise highest revenues for the market in 2022?
  • How market leading players are successfully cashing in on the growing traction for freeze and thaw systems for R&D.
  • What are the key strategies of market big shots in freeze and thaw systems market?
  • Which end use witnessed most traction for freeze and thaw systems in 2018?
  • What rate of ROI can freeze and thaw systems market stakeholders expect from the growing application of these systems in academic and research institutes in the next five years?
  • What will be the Y-o-Y growth of freeze and thaw systems market between 2019 and 2022? 

Research Methodology – Freeze and Thaw Systems Market 

The research methodology adopted by the analysts for developing freeze and thaw systems market report is based on an exhaustive primary as well as secondary research. The analysts delved deep into the market-related information that are obtained by pertinent sources to present incisive insights and precise forecast of the freeze and thaw systems market. 

During the primary research, PMR analysts carried out interviews of leading market players to collect information related to the vital project objectives. As a part of the secondary research phase, they studied company annual reports as well as investor presentations. They also collected data from website or the press releases of the established market players, while also considering articles/reports published by reliable sources to attain better understanding of the freeze and thaw systems market.

The potential of cell therapies has been recognized for long, however, commercialization is a comparatively recent endeavor. Cryopreservation has become a crucial part of the manufacturing process, as it enables cell therapies to be efficiently stored as well as transported, however, all of this is only beneficial if cell viability is maintained. Biotechnological, pharmaceutical, and medical markets include several products that are lyophilized within their highly complicated manufacturing. This has led to the emergence of freezing and thawing for storage and transportation, which is increasingly considered essential for several products that aren’t freeze-dried. 

Though the market for freeze and thaw systems is quite young for now, however, it is highly likely to witness growth in the years to come. This falls in line with the fact that the biopharmaceutical sector needs to respond compliantly to quick demand as well as supply of products, and hold intermediate forms of products for some time between processing steps. For that matter, a viable method of storing and transporting sensitive products has become essential, which in turn has driven the development and adoption of freeze and thaw systems. As the number of biopharmaceutical companies continues to grow, demand for proper handling of sensitive and deterioration-products is also growing at a steady pace. In view of this growing demand for proper management of products at pharmaceutical and biotechnology companies and academic and research institutes, Persistence Market Research (PMR) decided to gauge the lucrativeness of freeze and thaw systems market

freeze and thaw systems market infographic

How Has Freeze and Thaw Systems Market Evolved? 

The accelerating freeze and thaw systems market has its roots deep into the long-practiced cryopreservation that has been performed widely for over years. The process of cryopreservation dates back to the 1950s, when it was widely adopted for shipping livestock sperm. Later, the process was applied to other cells, such as human blood cells, sperm, and embryos. A decade ago, regenerative medicine turned into a reality, and cells were being classified as medicinal products, which led to a dire need for better control over the freezing and thawing process. The PMR analysis showcased that the adoption of freeze and thaw systems reached ~3650 units in 2018, while accounting for revenues worth US$ 253.5 Mn in the same year. As per the PMR analysts the freeze and thaw systems market is envisaged to witness 2.0X growth during the forecast period. 

Compelling Trends that are Determining the Freeze and Thaw Systems Market Dynamics  

Importance of Bulk Product Production and Transport to Underpin Gains 

As a growing number of biotherapeutics are expensive to produce, manufacturers have placed their focus on producing bulk quantities of biological materials at one time to reduce production costs, while enabling them to offer low-priced products to consumers. Owing to the growing challenges pertaining to how to store bulk drug solutions safely and effectively for long durations of time, companies are increasingly leveraging freezing and thaw systems to prevent degradation of drug chemicals. While freeze and thaw systems allow manufacturers to maintain several drugs at a sub-freezing temperature till the time they need to be thawed for research or clinical usage, their adoption is anticipated to grow.

Dire Need for Novel Medicinal Inventions to Push Adoption of Freeze and Thaw Systems 

While a growing number of companies, academic and research institutes, contract research organizations are hard pressed to come up with new inventions to suffice the growing demand for novel therapies, drugs, and medicinal offering, demand for clinical study infrastructure is likely to grow. Rising health issues, coupled with a dire need to identify ways to face and overcome several chronic conditions has been creating an increased demand for novel and improved drugs, and therapies. This has further led to a growing demand for proper and safe storage and transportation of several cell based substances or hormonal drugs, among others. Such factors are estimated to pace up gains for the freeze and thaw systems market in the near future. 

Opportunities Lay Abound in Biopharmaceutical & Biotechnical Companies 

As the number of biopharmaceutical and biotechnical companies continues to accelerate at a rapid pace, the traction for devices and equipment they used to maintain the properties of temperature-sensitive biological stimulating agents has also increased considerably. While the unfavorable effects of freeze and thaw systems on the properties of several antibodies continue to garner limelight, stakeholders are hard pressed to leverage advanced technology to overcome potential sales restrains.  

What Are the Pain Points of Freeze and Thaw Systems Manufacturers? 

Companies Remain Adhered to Conventional Ways 

Rising concerns pertaining to the association between hampered properties of samples and the use of freeze and thaw systems have been narrowing down the growth potential of the market players. For instance, multiple cycles of freezing and thawing can damage protein structures, and can disrupt the research protein kinetics. In light of the fact that even a minor DNA damage can generate uninterpretable data from polymerase chain reaction (PCR), several research institutions and pharmaceutical companies continue to substitute the use of risky freeze and thaw systems with tested conventional counterparts. 

High Cost Denting Adoption 

The cost of different sized freeze and thaw systems vary considerably, while making most of them highly unaffordable for several biopharmaceutical companies and research centers. As multiple freeze and thaw systems don’t operate in synchronization for large batch size, large scale freeze and thaw systems remain the only choice for customers. This high cost of large scale freeze and thaw systems continues to make small scale and medium scale companies unable to invest in these variants, thereby narrowing down the sales prospects for stakeholders. 

Unknown Status of Single-use Bags  

Though the adoption of single-use bags generated ~US$ 87 Mn revenue in 2018 followed by shipper based products, the rapidly growing flaws of this product are creating a troublesome scenario for market players. Numerous flaws associated with the use of single-use bags during the logistics process or tiny holes upon delivery continue to question the utilization of this product. While such flaws can lead to loss of drug substance by rendering the high-quality liquid useless, they not only put the patient at risk but also paves the way to financial losses for the manufacturer. 

North America & Europe – Lucrativeness Defined 

Developed regions, such as North America and Europe continue to remain the hotbed of opportunities for companies operating in the freeze and thaw market. Massive presence of giant biotechnology and pharmaceutical companies and contract research organizations has been creating a demand for proper sample and protein drugs storage systems, such as freeze and thaw systems in the region. Rapidly advancing infrastructure, coupled with the dire need for improvised and advanced drugs, cell therapies, has been driving the demand for viable systems for storing and transporting highly volatile chemicals and drugs in the region. Several market players are also penetrating the less explored regions, such as Asia Pacific to expand their reach and strengthen their market position. Growing demand for efficient and quick clinical trials in several Asian regions is highly likely to create increased traction for proper sample storage and transportation systems, thereby paving way for a stream of opportunities for market growth.

freeze and thaw systems market segmentation

Strategic Partnerships & Acquisitions – The Way Forward 

Collaboration, acquisitions and agreements between key payers operating in the market with academic institutions and universities continue to expand, creating new dimensions and opportunities for the development of products, such as single use bags and shippers. For instance, in March 2019, BioLife Solutions, Inc acquired a biotechnology company Astero Bio Corporation to enhance and expand its product offerings. 

Mapping the Freeze and Thawing Systems Market Structure 

The freeze and thaw systems market shows a high level of consolidation due to the presence of numbered players worldwide. The top four players, including HOF Sonderanlagenbau GmbH, Thermo Fisher Scientific, Inc., Sartoriuos AG, and GE Healthcare Life Sciences collectively held ~65% market revenue share in 2018. Though the stakeholders have been facing considerable bottlenecks owing to numerous loopholes of freeze and thaw systems, their increased focus on leveraging advanced technology is likely to help the market gain pace through 2029. 

Corporate tie-ups amongst the manufacturers of freeze and thaw systems and research institutions to better understand the efficacy and productivity of the systems remain a key growth strategy of stakeholders. Stakeholders are also collaborating to develop low cost and highly effective systems that are focused on appealing the small scale and mid-scale companies. 

Analyst’s Viewpoint 

The analysts of the report forecasts a steady rise in the freeze and thaw systems market, which is envisaged to expand at ~7% CAGR during 2019-2029, owing to the potential increase in the demand for proper storage and transportation infrastructure and systems for research samples and cell based substances. The stakeholders that have placed their focus on leveraging advanced technology to develop low-cost and energy-efficient smart freeze and thaw systems are likely to emerge as the market frontrunners in the forthcoming years.  

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In the biopharmaceutical industry, freeze & thaw systems are used for performing all vital primary manufacturing processes. Freeze & thaw systems are containers, which are used for process development in biopharmaceutical industries. Along with these systems, freeze & thaw bags are also used for the same purpose. Freeze & thaw systems consist of three prime components - cooling and heating unit, transporting unit, and thawing unit. The advantage of freeze & thaw systems is that these can be used in lab-based research to freeze and thaw with minimal effort. Based on product type, freeze & thaw systems are further classified into four categories, which are freeze & thaw modular platforms, controlled rate chambers, single-use bags, and shippers.

Freeze & thaw modular platforms are designed in such a way that these are capable of accommodating a high degree of flexibility for different capacities/volumes. Additionally, all system components can integrate seamlessly with each other, which allows customization of systems according to various process needs. A modular freeze & thaw platform is available in three types depending on the scale of its use: lab scale, small/pilot scale, and large scale.

Demand for Disposable Freeze and Thaw Systems in the Market

Over the years, the demand for disposable freeze & thaw systems has increased. Biopharmaceutical companies have been the major end users of freeze & thaw systems. They are switching from traditional stainless steel-based freeze & thaw systems to disposable ones in order to increase their manufacturing capacities and aseptic transfer of products. Freeze & thaw disposable systems have greatly reduced the drawbacks associated with stainless steel systems, which are used for specific product lines and also lack in operation efficiency. In comparison, disposable freeze & thaw bags have higher capacity and effective freeze and thaw capabilities. These systems can also be used to track and monitor the progress of freezing through temperature sensors and monitoring equipment.

Market Penetration in Untapped Regions an Opportunity to Increase Revenue

Manufacturers of freeze & thaw systems could focus on reaching out to consumers in many untapped regional freeze & thaw markets to increase sales and generate revenue from developing economic regions such as the BRICS consisting of Brazil, Russia, India, China, and South Africa. There are many other regions where different types of freeze & thaw systems are imported from leading manufacturing countries. This invariably leads to high product cost, which affects revenue generation from these regions. Therefore, companies are focusing on manufacturing their devices and systems in these regions either by establishing their own manufacturing hub or through OEM agreements, to offer products at comparatively lower costs. This will lead to the growth of the freeze & thaw market in untapped regions, which successfully can contribute to the overall revenue generation in the global freeze & thaw market.

Growth Opportunities in North America and Europe

North America continues to be a prominent market for freeze & thaw systems. The region’s growing research & development includes presence of massive biotechnology companies, contract research organizations, and contract manufacturing bodies. Europe is anticipated to be among the leading regional markets of freeze & thaw systems due to the growing number of contract research organizations in the region. In Europe, Germany will lead the freeze & thaw regional market due to the presence of highly productive contract research service providers. Besides, increasing sales force is also likely to expand product reach across these two regions through distribution & collaboration agreements. These opportunities will lead to the market growth of freeze & thaw systems in these regions.

Flaws in Single-Use Bags May Hamper the Overall Growth of the Market

In spite of all the advantages, it cannot be ignored that single-use bags are associated with certain manufacturing defects. Freeze & thaw bags can be damaged during logistics process or during transportation. They can be severely ruptured by some of the external factors or mechanical force. Additionally, single bags can be faulty upon delivery. Moreover, tiny holes can cause the contamination of the entire bag content. These can lead to “loss of active drug ingredients” which can render high-quality liquids useless. This can not only create threat for the patient but also lead to financial loss for the manufacturer.

Company Profiles:

  • BioLifeSolutions, Inc.
  • CARON Products & Services, Inc.
  • Farrar Scientific
  • GE Healthcare Life Sciences
  • HOF Sonderanlagenbau GmbH
  • Meissner Filtration Products, Inc.
  • Precision Cryosystems
  • Sartorius AG
  • Single Use Support GmbH
  • Thermo Fisher Scientific, Inc.
  • W. L. Gore & Associates, Inc.
  • ZETA Holding GmbH

 

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