Serum-Free Media Market: About the Report
On the back of high use of serum-free media in the biopharmaceutical sector, especially for drug development and cell culture, the global serum-free media market is set to more than double its size over the next ten years. PMR’s report elaborates on why CHO cell media plays an important role in this industry. Though North America holds the largest share in the global serum-free media market, and will continue to do so through 2030, market players can also look to the Asia Pacific region, which will offer increasing lucrative opportunities for growth as the years go by.
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- Thermo Fisher Scientific Inc.
- Merck KGaA
- GE Healthcare
- Corning Incorporated
- Irvine Scientific
- STEMCELL Technologies Inc.
- PAN Biotech
- MP Biomedicals, LLC
- PromoCell GmbH
Serum-Free Media Market Trends
Defined Composition and Lower Risk of Infectious Agents Driving Market Growth: Serum media is an often poorly defined cell culture medium. Depending on the source of serum, the composition of serum media may vary, which results in poor production and misinterpretation of results. Whereas, all the compositions of serum-free media are known with actual amount of each component added in it, which makes it a defined media and offers consistent cell culture growth with superior output.
Serum can be contaminated by disease-causing bacteria, fungi, and other components. It has been one of the major concerns for biopharmaceutical manufacturers. It lowers the adaption animal component-based media for manufacturing processes. Moreover, serum-free media eliminates the contamination risk during experiments, which makes it a preferred medium for cell culture. These factors are aiding the expansion of the global serum-free media market size, globally.
Comparatively Easier Downstream Process with Least Risk of Contaminants to Drive Demand: The defined nature of serum-free media often makes the process of purification easier as compared to serum media, which is termed as undefined media. Known composition of serum-free media often with added components for cell growth instead of serum eliminates the long procedure, providing better cell growth. The type and quantity of each component added into serum-free media is known to help in the precise evaluation of each component added to it. However, in serum-free media, the protein content is significantly reduced, which make downstream processing simple as compared to serum media. It reduces the contamination of downstream processing, and makes it much easier to control cell environment in serum-free media.
Serum often has the tendency to bind any of the other component of the media, or it may start degrading on its own, which increases the risk of interaction, resulting in flawed results. This risk is eliminated in case of serum-free media. In case of serum media, protein concentration of serum is so high that it might be higher than the recombinant protein produced by mammalian cells. If the serum protein and recombinant protein are similar in nature, it makes differentiation very difficult, whereas, in serum-free media, protein concentration is low, which significantly decreases the chances of such a scenario. On the back of these favourable factors, the global serum-free media market is projected to expand at a healthy pace over the next ten years.
Increasing Biopharmaceutical Production with Adoption of Serum-Free Media: Rapidly growing biopharmaceutical industries and increasing biopharmaceutical production are creating opportunity for the growth of the serum-free media market. Higher potency of biopharmaceuticals in treating various diseases is further making them the choice of treatment, which, in turn, increases biopharmaceutical production. With constantly-evolving manufacturing techniques, molecules, and various other factors, adoption of biopharmaceuticals in the healthcare industry in on the rise at an unprecedented rate, which is expected to create vast opportunity for the growth of the serum-free media market over the coming years.
The biopharmaceutical industry makes significant contribution to the U.S. economy. Moreover, the U.S. FDA and European Union approved 155 biopharmaceutical products in 2018. Besides that, 57 of the 68 mAb products approved in 2018 were produced in the CHO cell culture system. This indicates the large number of biopharmaceuticals in developmental phase.
In biopharmaceuticals, from the start of the R&D process to approval, it takes around 10 - 15 years to develop a medicine, and only 12% medicines entering clinical trials get approval, with more than US$ 2.6 Bn spent to develop each medicine, including the cost of failure. In 2019, the Center for Drug Evaluation and Research approved 48 new drugs; 28% of them were biologics.
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Regional Outlook of Serum-Free Media Market
North America holds a significant serum-free media market share, due to increased biopharmaceutical industrialization. In Asia, there is significant demand for serum-free media due to rise research & development activity. Moreover, growing biopharmaceutical industries in the region also fuel the growth of the market. In the Asia Pacific region, there is significant demand for CHO cells by media type due to the high rate of adoption of CHO cells for research purposes. Countries such as the U.S., Germany, India, and Japan implement collaborative research as well as government initiatives, which is expected to further support the growth of the serum-free media market in these regions.
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COVID-19 Impact on Serum-Free Media Market
The global outbreak of COVID-19 has had a negative impact on the serum-free media market. In the 1st quarter of 2020, the pandemic created a short-term decline in manufacturing and sales of serum-free media, as a result of lockdowns and less production at manufacturing facilities. As time goes by, the global serum-free media market will gradually get back to its normal growth trajectory.
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A detailed study of the serum-free media market has brought our analysts to an interpretation that, the market is growing at a remarkable pace. Currently, CHO cell media is the most lucrative segment for leading manufacturers. Thus, this segment dominates the global serum-free media market by media type in terms of market growth. Currently, North America holds nearly thirty percent of the global revenue share, due to increasing number of biopharmaceutical industries in the region. Emerging economies such as India, Brazil, and Thailand are expected to offer lucrative opportunities for players in the serum-free media market growth, owing to increasing research & development activities in the region.