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Opioids Market

Effective Use of Opioids in Pain Management is set to drive the Opioids market in future

Opioids Market Segmented By Morphine, Codeine, Fentanyl, Meperidine, Methadone Product in Analgesia, Cough Suppression, Diarrhea Suppression

Opioids Market Outlook (2023-2033)

Worldwide revenue from the opioids market stands at US$ 42.9 Bn in 2022, with the global market estimated to surge ahead at a CAGR of 3.3% to reach a valuation of US$ 61.1 Bn by the end of 2033.

Opioids Market Size (2022)

US$ 42.9 Bn

Projected Market Value (2033)

US$ 61.1 Bn

Global Market Growth Rate (2023-2033)

3.3% CAGR

Market Share of Top 5 Countries


As assessed by Persistence Market Research, morphine is expected to hold a largest market value of US$ 15.9 Bn by 2023. Overall, opioids market sales account for approximately 55.6% revenue share in the global analgesics market, which was valued at around US$ 77.3 Bn at the end of 2022.

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Sales Analysis of the Global Market from 2016 to 2022 Vs Market Outlook for 2023 to 2033

The global market for opioids recorded a historic CAGR of 2.7% in the last 6 years from 2016 to 2022.

The Opioids Market is anticipated to grow as a result of an increase in the number of patients with chronic diseases like cancer and Chronic Pulmonary Obstructive Disease (COPD), as well as an increase in the number of prescription drugs for post-operative pain relief and various trauma situations that causes pain.

  • For instance, according to a WHO study (2020), COPD was the third leading cause of mortality worldwide in year 2020, with a combined prevalence of 15.70% in men and 9.93% in women.

Clinical practise standards place strict restrictions on the prescription of opioids in order to safeguard patient safety, provide them with an appropriate course of treatment, and prevent overuse, abuse, and overdose. As a result, the commercial usage of opioid medicines is being strengthened, leading to an increase in their consumption.

  • For instance, the Secretary of Health and Human Services (HHS) is mandated to ensure the safe use of prescription medications having abuse potential under Section 1122 of the Food Drug and Cosmetics Act (FDASIA).

According to the New Global Cancer statistics, there were around 19.3 million cases of cancer worldwide and 10 million cancer-related deaths in 2020. Out of all cancer patients, 50 to 70 percent require analgesics to control their discomfort. The world's cancer burden is predicted to increase to 21.7 million cases by 2030, primarily as a result of an ageing population. Thus, it is anticipated that the opioids market will be driven by the increased prevalence of cancer and the ageing population.

The opioid demand will rise in the future as neuropathic pain is becoming more prevalent. According to the NCBI study (2021), 14.6% of individuals had neuropathic pain. 25.1% of patients with neuropathic pain had genetic or idiopathic neuropathy and 27.3% experienced neck and back pain. These numbers are expected to surge in the in the coming times, ultimately resulting in high demands for opioids.

The global market is thus likely to show high growth over the coming years at a CAGR of 3.3% and reach a global market size of US$ 61.1 Bn by 2033.

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What Factors Will Drive the Market to Grow Over Forecast Period?

Demographic Expansion to Uplift the Market

The growth of the opioids market is anticipated to be fuelled by the expansion of companies supplying novel and affordable opioids, particularly in African and South American countries. Companies with patent rights to specific opioid medications are focusing on potential markets, particularly in Africa. In order to commercialize their products, these companies are seeking permission from the relevant government authorities.

  • For instance, In August 2020, Trevena Inc. received U.S.FDA approval for Olinvyk (oliceridine), an opioid agonist for the pain management in adults.

“Rising Awareness Regarding Opioids in Pain Management”

According to NIH (National Institute of Health), individuals with moderate to severe pain are typically treated with opioids, while some of the prescribed opioids can also be used to treat cough and diarrhoea. Since the last few years, there has been an increase in demand for opioids, particularly for drugs that are used to treat pain. The introduction of Opioids Maintenance Treatment (OMT), and rising awareness of palliative care have all contributed to an increase in the demand for opioids worldwide.

“Patients with Chronic Diseases to Create High Demands”

Increased prescription of painkillers during post-operative procedures and an increase in patients with terminally chronic diseases including HIV, and severe cough brought on by lung infections are two causes that are anticipated to increase opioid use as a pain reliever. Additionally, the demand for opioid medications is being fuelled by the growing pain management awareness programmes being offered by local governments, NGOs, regulatory agencies, and healthcare systems in across nations.

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Is there Any Impact on the Growth of the Opioids Market?

Severity of Abusive Opioids and their Misuse Have Decreased their Sale

Practitioners have reduced the amount of opioids they prescribe for pain relief as a result of the severity of their abuse and misuse, which has decreased opioids overall sales globally. About 20%-30% of opioids prescribed for chronic pain are misused, according to the International Association for the Study of Pain (IASP). In addition, the association claims that up to 10% of all opioid users are addicted.

“Adverse Side Effects”

Chronic opioid side effects are a significant obstacle to the growth of the market.

For instance, heavy morphine use may cause severe respiratory depression, which occasionally even results in coma and ultimately death. Long-term morphine use may result in physical and psychological addiction as well as immune system degradation.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are known to have side effects that can affect the cardiovascular, GI, and excretory systems.

  • The use of NSAIDs can increase liver enzyme levels and possibly harm the liver. Around 60% of individuals who use conventional NSAIDs experience GI side effects, which can be dangerous.
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Country-wise Insights

Why is the U.S. Market Booming?

“Growing Adoption of Analgesics for Pain Treatment”

The U.S. accounted for around 93.1% market share in the North America opioids market in 2022.

Adoption of analgesics for pain treatment is being supported by rising awareness of palliative care for terminally ill patients. The prevalence of pain in chronic disease conditions is over 75%, and rising awareness of palliative care services in the U.S. is expected to fuel the expansion of the opioids market.

Will Germany Be a Lucrative Market for Opioids Manufacturers?

“High Demand for Chemotherapy”

Germany held around 18.1% market share of the Europe opioids market in 2022.

Among cancer patients, there is a high demand for chemotherapy, which magnifies cancer pain and other illnesses and increases the need for supportive care. Therefore, it is anticipated that the countries demand for opioids would increase as cancer incidence rates rise in Germany.

How is China Emerging as a Prominent Market for Opioids?

“Growing Geriatric Population Suffering with Terminal Illnesses”

China held a market share of about 67.8% of the East Asia opioids market in 2022.

The growing number of elderly people in China suffering from terminal illnesses is projected to increase demand for opioids all over the country. China has one of the world's fastest-growing ageing populations, according to WHO. Due to rising life expectancy and declining birth rates, 28% of China's population is expected to be over 60 by 2040.

Category-wise Insights

Which Product is Driving Growth of the Global Market?

“Wide Availability and Off-Label Sales”

Morphine held around 36.0% share of the total opioids market in 2022.

Morphine is the most frequently used opioid in pain management and it offers individuals suffering from pain significant relief. Treatment of aggressive cancer, vaso-occlusive pain during sickle cell crises, and palliative/end-of-life care are clinical circumstances that benefit tremendously from morphine medication. In addition, morphine is also used as painkiller off-label. Another reason for morphines' commercial dominance is their widespread accessibility and patients' specific preference for morphine as painkillers.

Which Application Has Dominated the Opioids Market Globally?

“Opioids as the Most Potent Medication for Pain Management”

Analgesia hold a market share of around 67.2% in 2022. For years, people have considered opioids to be among of the most potent medications for the treatment of pain. Most of the world views their use as the standard of therapy for the treatment of acute, severe pain and chronic pain due to advanced medical illness.

Estimates at the national level were produced in the U.S. by the National Health Interview Survey. They discovered that 50.2 million individuals (20.5%) reported experiencing pain frequently or daily using a chronic pain module included in the 2019 National Health Interview Survey. Opioid analgesics were the most often employed management techniques for chronic pain.

Which Distribution Channel Offers the Global Market a Profitable Outlook?

“Increasing Number of Hospitals Across the Globe”

Hospital Pharmacies held the larger share of about 31.5% with a market value of around US$ 13.5 Bn in 2022.

With the massive rise in hospitals around the world, pharmaceutical companies are anticipated to see a sharp increase in potential for hospital pharmaceuticals. The competitive environment is anticipated to get more intense as more significant pharmaceutical companies enter the oncology market, which is actually one of the most lucrative area of the sales segment in the hospital pharmacies. In the near future, patients are anticipated to favour hospital pharmacies over other pharmacies due to a significant increase in the prevalence of numerous chronic conditions including diabetes and cancer.

Competition Landscape

The opioids market is extremely consolidated, with a number of significant competitors involved. They are focusing on research and development activities primarily for pain medications as well as for other therapeutic potential, such as cough suppression and diarrhoea suppression, in several clinical and scientific fields. As a result, industry players are also attempting to broaden their geographic reach through product launches, mergers, and enhanced distribution networks.

Key instances include:

  • In August 2022, Onsolis, a branded opioid medication, was acquired by Adalvo from a reputable specialty pharmacy company in the U.S. This opioid is recommended for the treatment of cancer patients' chronic pain. This acquisition helped broaden the company's line of opioid products and presented a significant possibility for the company to expand.
  • In August 2020, Olinvyk (oliceridine), an opioid, was granted by the U.S. Food and Drug Administration to treat people with moderate to severe acute pain. This approval was given to Trevena, Inc., a biopharmaceutical enterprise, by the FDA.

Industry Report Scope



Forecast Period


Historical Data Available for


Market Analysis

USD Billion for Value

Key Countries Covered

  • U.S.
  • Canada
  • Brazil
  • Argentina
  • Mexico
  • Germany
  • France
  • U.K.
  • Italy
  • Spain
  • Russia
  • India
  • Thailand
  • Malaysia
  • Indonesia
  • China
  • Japan
  • South Korea
  • Australia
  • New Zealand
  • Turkey
  • GCC
  • North Africa
  • South Africa

Key Market Segments Covered

  • Product
  • application
  • distribution
  • channel
  • region

Report Coverage

  • Market Forecast
  • Competition Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives

Key Companies’ Profile

  • Pfizer, Inc.
  • Boehringer Ingelheim International GmbH
  • Janssen Pharmaceuticals, Inc.
  • Sanofi SAIS
  • Sun Pharmaceutical Industries Ltd.
  • Actavis Plc. [Teva Pharmaceutical Industries Ltd.]
  • Mallinckrodt Pharmaceuticals
  • Endo Pharmaceuticals Inc. [Endo International plc]
  • Purdue Pharma L.P.
  • Assertio Therapeutics, Inc. (Assertio Holdings, Inc.)

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Key Segments Covered in Opioids Industry Research


  • Morphine
  • Codiene
  • Fentanyl
  • Meperidine
  • Methadone


  • Analgesia
  • Cough Suppression
  • Diarrhea Suppression

Distribution Channel:

  • Hospital Pharmacies
  • Retail Pharmacies
  • Drug Store
  • Clinics
  • Others


  • North America
  • Latin America
  • Europe
  • South Asia
  • East Asia
  • Oceania
  • Middle East & Africa

- Companies Covered in This Report -

  • Pfizer, Inc.
  • Boehringer Ingelheim International GmbH
  • Janssen Pharmaceuticals, Inc.
  • Sanofi SAIS
  • Sun Pharmaceutical Industries Ltd.
  • Actavis Plc. [Teva Pharmaceutical Industries Ltd.]
  • Mallinckrodt Pharmaceuticals
  • Endo Pharmaceuticals Inc. [Endo International plc]
  • Purdue Pharma L.P.
  • Assertio Therapeutics, Inc. (Assertio Holdings, Inc.)

- Frequently Asked Questions -

The global market is currently valued at around US$ 42.9 Bn in 2022.

Sales of the market are set to witness growth at a CAGR of 3.3% and be valued at around US$ 61.0 Bn by 2033.

Demand for the market increased at a 2.7% CAGR from 2016 to 2022.

U.S., China, the UK, Germany, and France accounted for the major share in the global market as of year 2022, holding around 69.1% market share.

The U.S. accounts for around 93.1% share of the North American market in 2022.

Latin America is estimated to grow at a CAGR rate of 4.0% over the forecast duration.

China market held a share of about 67.8% in the East Asia opioids market in 2022.

Germany held about 18.1% of the regional market share at the end of 2022.

Brazil held more than one third of the regional market share at the end of 2022.

India is expected to grow at a CAGR of close to 2.8% over the forecast period.

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