Recombinant Cell Culture Supplements Market

Global Market Study on Recombinant Cell Culture Supplements: Demand Surging for Use in Regenerative Medicine and Gene Therapy Research Programs

Recombinant Cell Culture Supplements Market Segmented By Stem Cell Therapy, Gene Therapy, Bioprocess Application, Vaccine Development Application by Animals, Microorganisms, Human Sources for Recombinant Growth Factors, Recombinant Insulin, Recombinant Albumin, Recombinant Transferrin, Recombinant Trypsin, Recombinant Aprotinin, Recombinant Lysozyme

  • February-2021
  • PMRREP31310
  • 309 Pages
  • Healthcare

About the Report

Recombinant cell culture supplements are mostly used in stem cell research, gene therapy, and bioprocess development. These supplements and growth factors are applied to stem cells for culture expansion or to drive differentiation into specific cell types. Stem cell research will continue to expand, advance, and gain adoption over time. Key manufacturers such as Merck KGaA, Thermo Fisher Scientific, Inc., and Hoffmann-La Roche Ltd have their distribution facilities, manufacturing sites, and offices, globally. Emergence of e-Commerce is also leading to increased accessibility of recombinant cell culture supplements from prominent players.

In its new study, Persistence Market Research offers insights about key factors driving demand for recombinant cell culture supplements. The study points toward mammalian recombinant cell culture supplements being the most sought-after. Biopharmaceutical companies hold close to one-third of the market share, globally. The report also tracks global sales of recombinant cell culture supplements in over 20 high-growth markets, along with analysis of the impact of COVID-19 on the life science industry in general, and recombinant cell culture supplements in particular.

The COVID-19 pandemic surged demand for recombinant cell culture supplements, owning to shifted focus toward COVID-19 research and stem cell research. Demand for these supplements increased during the pandemic. Supply chain crisis during lockdowns affected sales; however, sales resumed later on without adversely impacting the market.


Find Out More about the Report Coverage


  • Thermo Fisher Scientific
  • Merck KGaA
  • Lonza Group AG
  • F. Hoffmann-La Roche AG
  • Abcam PLC.
  • Hi-Media Laboratories
  • Becton, Dickinson and Company
  • STEMCELL Technologies Inc.
  • Fujifilm Corporation (Irvine Scientific)
  • InVitria (Ventria Bioscience)
  • Biocon
  • Cell Sciences, Inc.

What is the Future Demand Scenario for Recombinant Cell Culture Supplements?

Demand for recombinant cell culture supplements has been exponentially rising since the last few years. Moreover, increasing focus on stem cell research and oncology research has created a gateway for manufacturers of recombinant cell culture supplements. Recombinant products have advantages such as cost effectiveness in manufacturing and bulk production of supplements/growth factors. Recombinant DNA technology has revolutionized the pharmaceutical approach in developing therapeutics and research aiding products.

The recombinant cell culture supplements market is significantly expanding due to the development of novel therapeutics and biopharmaceuticals or biologics. Rapid growth of drug discovery programs is expected to boost demand during the forecast period. Demand for biologics and animal-free products is anticipated to transform the future of the biopharmaceutical industry.

All these factors are expected to create opportunities for the expansion of the recombinant cell culture supplements market size over the forecast period, which is projected to expand at a CAGR close to 7% through 2031.

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What is the Impact of Market Consolidation Activities on Recombinant Cell Culture Supplement Demand?

Given the consolidation in the market, key players are focusing on strategic acquisitions. This trend is observed throughout North America, Europe, and Asia Pacific countries.

  • For instance, in 2017, Thermo Fisher Scientific Inc. acquired Finesse Solutions, Inc., a key player in the development of scalable control automation systems and software for bio production.
  • Merck KGaA acquired Sigma-Aldrich in November 2015, and as such, became a key player in the recombinant cell culture supplements market.

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Why are Investments in Production Key to Market Growth?

Manufacturers are investing in the sector of cell culture media and its derivatives for production. Cell culture media is the most important ingredient in bio manufacturing and development & production of therapeutics. Cell culture supplements such as cytokine, growth factors, amino acids, vitamins, fatty acids, and lipid have been developed to support the growth of a wide range of cell lines.

Manufacturers are focusing on the expansion of production facilities to gain significant growth in the market.

  • For instance, in 2018, GE Healthcare Life Science announced the increase of annual production capacity for cell culture media & supplements
  • In July 2019, FUJIFILM Irvine Scientific announced the construction of a new cell culture media manufacturing site in the Netherlands, Europe. FUJIFILM Irvine Scientific has 3 production facilities in the field of bio production, cell, and gene therapy.

Increasing investments and manufacturing capacity expansion are expected to favor the growth of the growth factors market over the forecast period.

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How Does Emergence of Academia for Basic Research Impact Recombinant Cell Culture Supplements?

Academic research institutes have concentrated on advancing basic research, which also includes applied research. On the other side, government or industrial organizations prefer cost-effective ways to follow development programs. A majority of basic research continues to be carried out at academia, as companies focus on bringing products to the market with an eye on generating profits. According to the National Science Foundation’s 2012 report, 56% of basic research conducted in the U.S. is carried out in academia, whereas, 61% of all applied research and 87% of development happens in the industry.

Strong scientific and technological expertise available with academic research laboratories ensures that they continue to be the most reliable group to carry out basic research programs.

Will Increasing Demand for Regenerative Medicine Push Recombinant Cell Culture Supplement Sales?

Regenerative medicine is a part of medicine that deals with the process to repair, replace, or regrow damaged and diseased cells, tissues, or whole organs that have been lost or disturbed due to congenital defects, aging, disease, or damage.

Recombinant cell culture supplements provide biochemical signs for stem cell separation, and are used to develop unique strategies to treat human diseases by inspecting cellular processes controlling development, aging, and tissue regeneration. Modulation of growth factors at the injury site is one of the strategies to stimulate tissue regeneration

Growth factors play an important role in vascular and hematopoietic, neural, skeletal, pancreatic, periodontal, and mucosal tissue regeneration. Recombinant growth factors such as platelet-derived growth factors and bone morphogenetic factors are gaining high demand for diabetic neuropathic ulcers and periodontal defects, tissue regeneration at sites of tibia fracture and nonunion, and tissue regeneration for tibia nonunion. Increasing demand for recombinant cell culture supplements in regenerative medicine and gene therapy research programs is expected to propel market growth over the coming years.


Country-wise Insights

Why does China witness significant demand for recombinant cell culture supplements?

Mammalian cell culture techniques have been advancing over time. China can be said to be a leader in terms of adoption of technologies. Cell culture techniques such as cell-based assays have been extensively used in drug discovery. China is the hub for contract research activities in the world. Growing drug discovery and research activities in China play a vital role in increasing the adoption of recombinant cell culture supplements. China is one of the biggest biopharma industries in the world. In addition to this, China has a high number of domestic pharma companies. Moreover, the Chinese government provides financial support for ongoing life science research.

How will increasing oncological research and expanding therapeutic pipeline surge demand in the U.S.?

Recombinant cell culture supplements are an important part of cancer research. The connection of recombinant growth factor families and oncogenes has led to better understanding of carcinogenesis as well as providing new targets for chemotherapy. Recombinant growth factors such as vascular epithelial growth factors, epidermal growth factors, fibroblast growth factors, and platelet-derived growth factors have an important role in cancer research and diagnosis. Cell culture has also helped oncology research the most, as cancer cells are more responsive to culture in vitro.

Premium institutes such as the National Cancer Institute (NCI) and others invest in major research initiatives to enable and support research on specific issues of importance to cancer research enterprises. The National Cancer Institute had earlier invested in initiatives such as Cancer Moonshot, The National Clinical Trials Network (NCTN), NCI Genomic Data Commons (GDC), the RAS Initiative, NCI Community Oncology Research Program (NCORP), etc. Growing research and development funding in the field of oncology is expected to drive the growth of the global growth factors market.

What is the impact of the growing contract research industry on India’s recombinant cell culture supplements market?

In recent years, small and large biopharmaceutical companies have become increasingly dependent on contract research organizations (CROs) and other clinical services to provide research services to their R&D operations. However, stem cell and growth factor-based products are expected to drive the market, as most products in the pipeline are likely to reach the end stage and be commercialized by the end of the decade.

In developing countries, it is easier to recruit patients for clinical trials. Clinical trial and research is now a major business in India, owing to numerous government-funded medical and pharmaceutical institutions with state-of the-art facilities, which can serve as ideal centers for multi-centered clinical trials. R&D costs in India are substantially less as compared to those in developed countries, and it is possible to conduct both, new drug discovery research and novel drug delivery system programs at competitive rates.

In terms of cost efficiency, India is better, as the cost to conduct a trial in the country is 50% to 75% less as compared to that in the U.S. or the European Union.

How the presence of recombinant cell culture supplement companies aiding the European Union?

Among the European countries, Germany is expected to be the leader in recombinant cell culture supplements, and is anticipated to witness significant growth over the forecast period. As per Persistence Market Research analysis, France will also progress substantially in this space. Presence of some prominent players such as Thermo Fisher Scientific Inc., Merck KGaA, Lonza, and Becton, Dickinson and Company in Europe will create remarkable returns for the region. Moreover, growing contract research manufacturing and research & development activities in the U.K. will also create high demand for recombinant cell culture supplements within the country. Companies and research institutes within Germany and the U.K. have an extensive pipeline in therapeutic areas such as cancer.

Category Insights

How is increasing demand for animal-free recombinant cell culture supplements impacting the industry?

Manufacturers are focusing on the introduction of animal-free recombinant cell culture supplements in the market as demand for these products is growing. Animal-free products eliminate the risk of contaminating cell culture media. Animal-free products are manufactured using an all human production system. No animal-derived cells are used in the manufacturing of this type of cytokines and growth factors. Animal-free recombinant cell culture supplements are free of animal components, serum, endotoxin, and endogenous mammalian contamination, and, as such animal-free recombinant cell culture supplements remain contaminant-free.

Large number of manufacturers offers animal-free growth factors in their product portfolios. For instance, Applied Biological Materials Inc., Peprotech, Cell Application Inc., AMS Biotechnology (Europe) Limited, Gemini Bio Products manufacture animal-free growth factors.

Animal-free growth factors & recombinant cell culture supplements are gaining high adoption in various research applications, which is expected to boost growth of the global recombinant cell culture supplements market over the coming years.

Competitive Landscape

The recombinant cell culture supplements market is highly consolidated in nature, with more than 10 key players operating in the market. The global market is dominated by prominent manufacturers - Thermo Fisher Scientific Inc., Merck KGaA, and Becton, Dickinson and Company, Lonza, and Hi-Media Laboratories. Majority of these manufacturers are focused on offering of a wide range of recombinant cell culture supplements for multiple applications such as stem cell research, oncology research, and bioprocessing. Manufacturers are focusing on research and development activities as application of recombinant cell culture supplements in various clinical and research fields.

With this, market players are also engaged in expanding their global and regional presence through acquisitions and expansion strategies.

  • In November 2015, Merck KGaA acquired Sigma-Aldrich and this acquisition bolstered both the companies to become a world leader life science solution provider.
  • In 2015, Abcam came into a partnership agreement with A-STAR's Institute of Molecular and Cell Biology, to manufacture high-quality immunoassays for life science research.
  • In October 2018, Thermo Fisher Scientific Inc. acquired the advanced bioprocessing business of BD (Becton, Dickinson and Company), a leading global medical technology company.

Some of the leading companies operating in the market are:

  • Thermo Fisher Scientific Inc.
  • Merck KGaA
  • Lonza
  • Abcam PLC.
  • Hi-Media Laboratories
  • Becton, Dickinson and Company
  • STEMCELL Technologies Inc.
  • Fujifilm Corporation (Irvine Scientific)
  • Biocon

*The list is not exhaustive, and only for representational purposes. Full competitive intelligence available in the report.

Scope of Report



Forecast Period


Historical Data Available for


Market Analysis

USD Million for Value and Units for Volume

Key Regions Covered

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia
  • Oceania
  • Middle East & Africa

Key Countries Covered

  • US
  • Canada
  • Brazil
  • Mexico
  • Argentina
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Poland
  • Russia
  • China
  • Japan
  • South Korea
  • India
  • Thailand,
  • Indonesia
  • Malaysia
  • Australia
  • New Zealand
  • South Africa
  • Turkey
  • North Africa
  • GCC Countries

Key Segments Covered

  • Product
  • Application
  • Source
  • End User
  • Region

Key Companies Profiled

  • Thermo Fisher Scientific Inc.
  • Merck KGaA
  • Becton, Dickinson and Company
  • Lonza
  • Fujifilm Corporation (Irvine Scientific)
  • Biocon
  • Abcam PLC.
  • F. Hoffmann-La Roche
  • Hi-Media Laboratories

Report Coverage

  • Market Forecast
  • Company Share Analysis
  • Competition Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives

Customization & Pricing

Available upon Request

Recombinant Cell Culture Supplements Market by Category


  • Recombinant Growth Factors
    • Transforming Growth Factor
    • Epidermal Growth Factor
    • Platelet-Derived Growth Factors
    • Fibroblast Growth Factor
    • Vascular Endothelial Growth Factors (VEGFs)
    • Interleukins 
    • Recombinant Stem Cell Factor
    • Other Growth Factors
  • Recombinant Insulin
  • Recombinant Albumin
  • Recombinant Transferrin
  • Recombinant Trypsin
  • Recombinant Aprotinin
  • Recombinant Lysozyme
  • Others


  • Stem Cell Therapy
  • Gene Therapy
  • Bioprocess Application
  • Vaccine Development
  • Others


  • Animals
  • Microorganisms
  • Human

End User

  • Academic and Research Institutes
  • Biopharmaceutical Companies
  • Cancer Research Centers
  • Contract Research Centers (CROs)


  • North America
  • Latin America
  • Europe
  • South Asia
  • East Asia
  • Oceania
  • MEA

Key Questions Answered in Report

Q1. Which is the most lucrative market for recombinant cell culture supplements?

The U.S., at present, holds the maximum market share and leads the global market for recombinant cell culture supplements. The U.S. is expected to experience significant demand for recombinant supplements over the entire forecast period.

Q2. Which application holds significant share in the market?

Stem cell therapy application holds the highest market share of one-third. Stem cell research continues to expand and advance with time, and stem cell treatment is gaining adoption across the world.

Q3. Which recombinant growth factors are prominent product types?

Emerging fields of stem cell and oncology research will enhance demand for recombinant growth factors in the future. Growth factor plays an important role in induced pluripotent stem cells differentiation into progenitor cells required for development, which are used in various cell biology. Growth factors are used in speeding up stem cell growth. Recombinant cell culture supplements and growth factors are gaining popularity due to clinical development and cellular therapies.

Q4. Which are the leading companies offering recombinant cell culture supplements?

Some of the prominent companies offering recombinant cell culture supplements are Thermo Fisher Scientific Inc, Merck KGaA, Lonza, and Hoffmann-La Roche Ltd, Biocon Ltd, and others.

Q5. What are the challenges associated with recombinant cell culture supplements?

Challenges associated with recombinant cell culture supplements can be manufacturing of the proteins and storage. As these proteins are highly fragile to extreme conditions such as heat, their half-life is very important for research. Degraded proteins cannot be used for experiments in research and development. Other challenges include purity of proteins and lot-to-lot consistency of products. As these products are used for cell culture techniques, they need to be ultra-pure and safe for the cells to uptake them.

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Is this research conducted by Persistence Market Research?

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