Neuroendocrine Carcinoma Treatment Market

Neuroendocrine Carcinoma Treatment Market Size, Share and Growth Forecast by Indication (Gastric Neuroendocrine Tumors, Lung Neuroendocrine Tumors, Pancreatic Neuroendocrine Tumors, Appendicular Neuroendocrine Tumors), by Treatment Type (Targeted Therapy, Chemotherapy, Surgery, Others), and by Region for 2024 - 2031

Neuroendocrine Carcinoma Treatment Market

Report ID: PMRREP34569

Report Type: Ongoing

Format: PPT*, PDF, EXCEL

Industry: Healthcare

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Neuroendocrine Carcinoma Treatment Market Size and Share Analysis

The global neuroendocrine carcinoma treatment market is estimated to value at US$4.2 Bn by the end of 2031 from US$1.97 Bn in 2024. The market is expected to secure a CAGR of 8.1% in the forthcoming years from 2024 to 2031.

Key Highlights of the Market

  • The emergence of radioligand therapy
  • The rise of targeted therapies that focus on specific mutations or pathways in neuroendocrine tumors, offering more precise and potentially less toxic options
  • Development of new medications tailored to address different types of carcinoid tumors, a sub-category of neuroendocrine carcinoma
  • Introduction of radiolabeled drugs like Lutetium-177 (Lu-177) for targeted radiation therapy of neuroendocrine tumors
  • Soaring popularity of combination therapy delivering the effectiveness of combining different treatment modalities, like targeted therapy and immunotherapy, for potentially better patient outcomes

Market Attributes

Key Insights

Neuroendocrine Carcinoma Treatment Market Size (2024E)

US$1.97 Bn

Projected Market Value (2031F)

US$4.2 Bn

Forecast Growth Rate (CAGR 2024 to 2031)

8.1%

Historical Growth Rate (CAGR 2019 to 2023)

7.6%

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Market Introduction and Trend Analysis

The NEC treatment market is expected to grow significantly over the next decade, driven by, increasing prevalence, and the development of new therapeutic options. Emphasis on personalized medicine and targeted therapies is likely to shape the future landscape of NEC treatment further.

Radioligand therapy represents a promising frontier in the treatment of neuroendocrine tumors (NETs), with peptide receptor radionuclide therapy (PRRT) emerging as a leading approach.

This therapy harnesses the specificity of peptide ligands to target overexpressed somatostatin receptors (SSTRs) on the surface of NET cells.

The targeted delivery of radiation enables precise tumor localization while minimizing damage to surrounding healthy tissues, offering a favorable therapeutic ratio.

  • In April 2024, Novartis, radioligand therapy, Lutathera® FDA approved as the first medicine specifically for pediatric patients with gastroenteropancreatic neuroendocrine tumors.

Radioligand therapies have extraordinary potential to shape the future of cancer care. With this approval, we have taken another vital step toward fulfilling that vision, strengthening our commitment to researching and developing the RLT platform across multiple cancer types and treatment settings.

PRRT has shown a favorable safety profile, with manageable side effects typically associated with radiation therapy, such as hematological toxicity and gastrointestinal symptoms.

Patient selection and pre-treatment imaging using somatostatin receptor scintigraphy or positron emission tomography (PET) are essential for identifying individuals who are likely to benefit from PRRT and optimizing treatment planning.

The increasing interest in PRRT reflects its potential to fill an unmet need in the therapeutic armamentarium for NETs, offering a targeted and effective treatment option with the potential to improve patient outcomes and quality of life.

Ongoing research efforts aim to further refine PRRT protocols, explore novel radionuclides and peptide ligands, and investigate combination strategies. These efforts further enhance treatment efficacy and broaden its applicability across diverse patient populations.

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Historical Growth and Course Ahead

The neuroendocrine carcinoma treatment market exhibited steady growth from 2015 to 2023, driven by increasing incidence rates and advancements in diagnostic techniques. The period saw the introduction of targeted therapies and immunotherapies, significantly improving patient outcomes.

The market is expected to continue growing due to ongoing advancements in treatment methodologies. Expansion in emerging markets and increased healthcare expenditure is likely to further drive market growth.

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Market Growth Drivers

Increase in Prevalence of Neuroendocrine Carcinoma

The rise in prevalence can be attributed to various factors, including improved diagnostic capabilities, heightened disease awareness, and demographic shifts such as an aging population.

Additionally, lifestyle factors and environmental influences may also play a role in the escalating incidence rates of this malignancy.

Healthcare systems are faced with the challenge of meeting the burgeoning demand for diagnosis, treatment, and supportive care services as the incidence of neuroendocrine carcinoma continues to climb.

Clinicians are witnessing a greater number of patients presenting with neuroendocrine tumors across various anatomical sites, necessitating multidisciplinary approaches to management.

Furthermore, the complexity and heterogeneity of neuroendocrine tumors underscore the importance of advancing research efforts to elucidate underlying molecular mechanisms and develop targeted therapies.

Innovative Drug Delivery Systems

Innovative drug delivery systems represent a paradigm shift in the field of oncology, offering unprecedented precision and efficacy in treating neuroendocrine carcinoma while mitigating the often-debilitating side effects associated with traditional therapies.

Among the most promising advancements are nanoparticle-based formulations and targeted drug delivery systems, which have garnered considerable attention for their potential to revolutionize cancer treatment.

Nanoparticle-based formulations utilize nanotechnology to encapsulate therapeutic agents within nanoparticles, allowing for precise control over drug release kinetics, and biodistribution.

These nanoparticles can be engineered to selectively accumulate within tumor tissues through passive targeting mechanisms, such as the enhanced permeability and retention (EPR) effect, or actively target tumor-specific receptors using ligands or antibodies.

Nanoparticle-based formulations minimize off-target effects and enhance treatment efficacy by delivering therapeutic payloads directly to cancer cells while sparing healthy tissues.

Nanoparticle carriers can overcome biological barriers, such as the blood-brain barrier, enabling the delivery of therapeutics to previously inaccessible sites of neuroendocrine carcinoma metastasis.

This unlocks new avenues for the treatment of advanced or metastatic disease, where traditional systemic therapies may be less effective.

Factors Impeding the Market

Difficulty in Accurately Diagnosing Early Stage Neuroendocrine Carcinoma

Neuroendocrine tumors (NETs) manifest across a spectrum of anatomical sites and exhibit considerable histological diversity, complicating their diagnosis.

This complexity arises from their ability to originate from neuroendocrine cells dispersed throughout the body, leading to a broad range of clinical presentations.

The nonspecific symptoms associated with early-stage neuroendocrine carcinoma, such as abdominal pain, flushing, diarrhoea, and weight loss, often overlap with those of more common gastrointestinal disorders, contributing to diagnostic ambiguity.

The absence of specific biomarkers or imaging modalities exclusively tailored for neuroendocrine carcinoma further compounds diagnostic challenges.

While serum markers such as chromogranin A and neuron-specific enolase may aid in disease monitoring, their utility as primary diagnostic tools remain limited due to suboptimal sensitivity and specificity.

Conventional imaging techniques like computed tomography (CT) and magnetic resonance imaging (MRI) often fail to detect small or occult neuroendocrine tumors, particularly in anatomically challenging locations including the pancreas or small intestine.

Diagnostic challenges pose a significant obstacle in the timely and accurate identification of neuroendocrine carcinoma. Consequently, impeding effective treatment initiation and subsequently influencing market dynamics.

Patient Population Heterogeneity

The patient population heterogeneity inherent in neuroendocrine carcinomas represents a formidable restraint in the development of effective targeted therapies that can address the diverse molecular and clinical characteristics of these tumors.

Neuroendocrine carcinomas encompass a broad spectrum of neoplasms arising from neuroendocrine cells distributed throughout various organs, including the gastrointestinal tract, pancreas, lungs, and other sites.

This heterogeneity is manifested at multiple levels, encompassing variations in tumor biology, histological features, genetic alterations, and clinical behavior.

One of the primary challenges posed by patient population heterogeneity is the considerable diversity in tumor differentiation and grade within neuroendocrine carcinomas.

These tumors exhibit a wide range of differentiation states, spanning well-differentiated, intermediate-grade, and poorly differentiated neuroendocrine neoplasms – each characterized by distinct clinical behaviors and prognoses.

Consequently, developing targeted therapies that effectively modulate specific molecular pathways implicated in tumor progression, and metastasis across this spectrum of differentiation poses a significant challenge.

The molecular landscape of neuroendocrine carcinomas is complex and heterogeneous, with diverse genetic alterations driving tumorigenesis and therapeutic resistance.

While certain genomic aberrations, such as mutations in genes encoding for MEN1, DAXX, and ATRX, have been identified as recurrent events in specific neuroendocrine tumor subtypes, the overall mutational landscape remains highly variable among individual tumors.

Genetic diversity not only underscores the multifactorial etiology of neuroendocrine carcinomas but also complicates the development of targeted therapies that can effectively modulate oncogenic signaling pathways across different tumor subtypes.

Future Opportunities for Neuroendocrine Carcinoma Treatment Providers

Increasing Shift Toward Combination Therapy Strategies

Combination therapy strategies present a promising opportunity in the treatment landscape of neuroendocrine carcinoma (NEC), offering a multifaceted approach to combat the heterogeneity and therapeutic resistance often associated with this malignancy.

By concurrently utilizing chemotherapy, targeted agents, and immunotherapies, clinicians can exploit distinct mechanisms of action to achieve synergistic effects.

Chemotherapy has traditionally been a cornerstone in the management of NEC, exerting cytotoxic effects on rapidly proliferating tumor cells. However, its efficacy is often limited by intrinsic or acquired resistance mechanisms.

By integrating targeted agents into treatment regimens, which selectively inhibit key molecular pathways implicated in NEC pathogenesis, clinicians can overcome resistance and enhance antitumor efficacy. For example,

  • Inhibitors targeting angiogenesis (e.g., bevacizumab) or growth factor receptors (e.g., everolimus) have demonstrated promising results in preclinical and clinical studies, potentially sensitizing tumors to chemotherapy and prolonging progression-free survival.
  • According to National Cancer Institute 2024, people with advanced neuroendocrine tumors in the digestive system may benefit from a treatment combination that includes the drug Lu 177-dotatate (Lutathera), according to the results of a first-of-its-kind clinical trial.

Moreover, the advent of immunotherapy has revolutionized cancer treatment paradigms by harnessing the immune system to recognize and eliminate tumor cells.

While immunotherapies such as immune checkpoint inhibitors (e.g., pembrolizumab, nivolumab) have shown remarkable efficacy in various malignancies, their role in NEC remains underexplored.

Nevertheless, emerging evidence suggests that combining immunotherapies with chemotherapy and targeted agents can elicit synergistic antitumor immune responses, augmenting the efficacy of each modality.

Category-wise Analysis

Category

Projected CAGR through 2031

 Indication - Gastric Neuroendocrine Tumors

8.5%

Application - Targeted Therapy

8.7%

Demand to Remain High for Treatment of Gastric Neuroendocrine Tumors

Gastric neuroendocrine tumors (G-NETs) play a significant role in driving the growth of the market. These rare tumors, originating from the neuroendocrine cells of the stomach, have garnered increasing attention due to advancements in diagnostic technologies and a deeper understanding of their pathophysiology.

Gastric neuroendocrine tumors are expected to witness a CAGR of 8.5% through 2031. The rising incidence of G-NETs, coupled with improved detection rates, has spurred the demand for innovative diagnostic tools and therapeutic options.

Moreover, ongoing research and development efforts aimed at enhancing treatment efficacy and patient outcomes have led to a burgeoning pipeline of novel therapies.

The growth of the neuroendocrine carcinoma treatment market is further bolstered by increasing awareness among healthcare providers and patients, fostering earlier diagnosis and intervention.

Targeted Therapy Application Takes the Lead

Targeted therapy has significantly contributed to the growth of the gastric neuroendocrine tumors (NETs) market by offering more precise and effective treatment options.

Unlike conventional chemotherapy, targeted therapy specifically attacks cancer cells with minimal damage to normal cells, resulting in better patient outcomes and fewer side effects. Targeted therapy is anticipated to expand at a CAGR of 8.7% through 2031.

Innovations in molecular biology have led to the identification of specific genetic and molecular targets in gastric NETs, allowing for the development of drugs that can inhibit tumor growth and progression.

These advancements have increased the demand for targeted therapies, thereby expanding the market. The rising prevalence of gastric NETs and the growing awareness among healthcare professionals and patients about the benefits of targeted therapies are further driving market growth.

Region-wise Analysis

Region

CAGR through 2031

North America

6.6%

Asia Pacific

8.1%

Substantial Investments in Cancer Research Sets Apart North America to Grow Substantially

The region's advanced healthcare infrastructure, which facilitates the early diagnosis and treatment of NEC.

High healthcare expenditure and substantial investment in cancer research contribute significantly to market expansion further expanding at a CAGR of 6.6% through 2031.

The presence of leading pharmaceutical companies and research institutions in the US, and Canada accelerates the development and approval of innovative therapies.

Moreover, the increasing prevalence of NEC, and heightened awareness among healthcare professionals and patients about the disease have boosted demand for effective treatments. Government initiatives and funding for cancer research further support market growth.

Asia Pacific Market Set to Bring Flourishing Prospects at a CAGR of 8.1%

The increasing prevalence of NEC, and other related cancers in the region has heightened the demand for effective treatment options.

The rise in incidence is partly attributed to improved diagnostic techniques and great health awareness, leading to earlier and accurate detection.

The economic development across many countries of Asia Pacific has resulted in enhanced healthcare infrastructure and increased healthcare spending, enabling better access to advanced medical treatments.

Also, the region has seen significant investment in medical research and development, particularly in countries like China, Japan, and India, fostering innovation and the introduction of new therapies.

Competitive Landscape Analysis

Strategic collaborations, and partnerships to develop innovative treatment options and accelerate the grant by regulatory bodies are the key growth strategies followed by the key players in the market. Companies are continuously investing in research and development to introduce innovative and breakthrough neuroendocrine carcinoma treatment.

Recent Industry Developments

June 2023

Jubilant Radiopharma and Evergreen Theragnostics Collaborated for the Sale and Distribution of Neuroendocrine Tumor Diagnostic OCTEVY™, (Kit for Preparation of Ga 68 DOTATOC Injection), pending FDA approval in 2H 2023.

Report Scope

Attributes

Details

Forecast Period

2024 to 2031

Historical Data Available for

2019 to 2023

Market Analysis

US$ Billion for Value

Key Regions Covered

  • North America
  • Europe
  • East Asia
  • South Asia & Oceania
  • Latin America
  • The Middle East and Africa

Key Market Segments Covered

  • By Indication
  • By Treatment Type
  • By Region

Key Companies Profiled in the Report

  • Pfizer Inc.
  • Novartis AG
  • Chiasma Inc.
  • Hutchison China MediTech Ltd
  • Abbvie Inc.
  • valeant Pharmaceuticals International Inc.
  • Jubilant Life Sciences Ltd.
  • Teva Pharamaceuticals Industries Ltd
  • F. Hoffman-La Roche Ltd
  • Advanced Accelerator Applications
  • Mateon Therapeutics, Inc.

Report Coverage

  • Market Forecast and Trends
  • Company Share Analysis
  • Competitive Intelligence
  • DROT Analysis
  • Market Dynamics and Challenges
  • Strategic Growth Initiatives  

Customization & Pricing

Available upon request

Market Segmentation

By Indication

  • Gastric Neuroendocrine Tumors
  • Lung Neuroendocrine Tumors
  • Pancreatic Neuroendocrine Tumors
  • Appendicular Neuroendocrine Tumors

By Treatment Type

  • Targeted Therapy
    • Tyrosine Kinase Inhibitors
    • mTOR Inhibitor
  • Chemotherapy
    • Antimetabolites
    • Alkylating Agents
    • Natural Products
  • Surgery
    • Curative Surgery
    • Palliative Surgery
  • Others

By Region

  • North America
  • Europe
  • East Asia
  • South Asia and Oceania
  • Latin America
  • The Middle East and Africa

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Companies Covered in This Report

Frequently Asked Questions

The increasing incidence and prevalence of neuroendocrine tumors globally is driving the market growth.

A few of the leading manufacturers of the market are Pfizer Inc., Novartis AG, and Chiasma Inc.

Gastric neuroendocrine tumors recorded a significant market share.

The growing adoption of personalized medicine approaches provide a fertile ground for innovation and market growth.

North America is set to account for a significant in the market securing 6.6% CAGR through 2031.

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