Global Market Study on Autologous Matrix-Induced Chondrogenesis (AMIC): Polyethylene Glycol (PEG) Segment Expected to Grow with a Healthy CAGR over the Forecast Period


  • Published On : Nov-2016 |
  • Pages : 113 Pages |
  • Format :

This report by Persistence Market Research examines the Autologous Matrix-Induced Chondrogenesis (AMIC) Market for the period 2016–2024. The primary objective of the report is to offer updates and information related to market opportunities in the global AMIC Market.

This report covers the global Autologous Matrix-Induced Chondrogenesis market performance in terms of revenue contribution. The report includes key trends, drivers, restraints, and opportunities influencing growth of the global Autologous Matrix-Induced Chondrogenesis market. Impact analysis of key growth drivers and restraints, based on the weighted average model, is included in this report to better equip clients with crystal clear decision-making insights.

The report starts with market overview and provides market definition and analysis about the drivers, restraints, opportunities, and key trends in the market. The following sections include analysis of the global market – by material and by region. These two sections evaluate the market on the basis of various factors affecting the market, covering the present scenario and future prospects. For market data analysis, the report considers 2015 as the base year, with the forecast provided for 2016–2026. 

The Autologous Matrix-Induced Chondrogenesis market is segmented as follows:

By Material

  • Hyaluronic Acid
  • Collagen
  • Polyethylene glycol (PEG)
  • polylactic-co-glycolic acid (PGLA)
  • Others

By Region

  • North America
  • Latin America
  • Europe
  • Asia pacific
  • MEA

In the final section of the report, a competitive landscape has been provided to present the client with a dashboard view of various comparison points including revenue bracket, key application areas, and global presence amongst others. It also enables identification and evaluation of key competitors based on in-depth assessment of their capabilities and success in the marketplace. Key players in the global Autologous Matrix-Induced Chondrogenesis market are Anika Therapeutics, Inc., Arthro-Kinetics, B. Braun Melsungen AG, BioTissue AG, CartiHeal, Geistlich Pharma AG, JRI Orthopaedics Ltd., Matricel GmbH, Smith & Nephew plc, and Zimmer Biomet Holdings.

Research methodology

A detailed analysis has been provided for every segment in terms of market size analysis for the global AMIC market. In order to offer an accurate forecast, we started by sizing up the current market, which forms the basis of how the global Autologous Matrix-Induced Chondrogenesis market is expected to develop in the future. Given the characteristics of the market, we triangulated the outcome of three different types of analysis based on supply side, downstream industry demand and the economic envelope.  

It is vital to note that in an ever-fluctuating global economy, we not only conduct forecast in terms of CAGR, but also analyze the same on the basis of key parameters such as, year-on-year (Y-o-Y) growth to understand the predictability of the market and to identify the right opportunities for market players. 

Another key feature of this report is the analysis of all segments in terms of absolute dollar. This is usually overlooked while forecasting the market. However, absolute dollar opportunity is critical in assessing the level of opportunity that a provider can look to achieve, as well as identify potential resources from a sales and delivery perspective in the global Autologous Matrix-Induced Chondrogenesis market. In addition to this, we have also provided strategic recommendations and key success factors for new entrants in the global Autologous Matrix-Induced Chondrogenesis market.  

Autologous Matrix-Induced Chondrogenesis (AMIC) is a biological treatment method to repair articular cartilage damage. AMIC therapy is a step-wise process. Micro fracture surgery is followed by application of a bi-layer collagen I/III membrane. It slows down cartilage degeneration with an intent to avoid or delay partial or total joint replacement (e.g. knee replacement) surgery. The indications for AMIC includes Grade III or IV chondral lesions with lesion size of about 2 cm­­2 to 8cm­­2.

In this report we have categorized the AMIC treatment according to the material type used in the procedure that includes Hyaluronic Acid, Collagen, Polyethylene glycol, polylactic-co-glycolic acid and others. The category others also includes some of the accessorial material like PLLA, agarose-alginate, chitosan, poly (ester-ether) polydioxanone. The global Autologous Matrix-Induced Chondrogenesis market has been segmented on the basis of material type and regions.

The global Autologous Matrix-Induced Chondrogenesis market is projected to register a CAGR of 8.6% during the forecast period in terms of value. The Global Autologous Matrix-Induced Chondrogenesis market value in 2016 is estimated to be US$ 96.11 million and is expected to increase to US$ 186.4 million by the end of 2024.

Market dynamics

Demand for minimally invasive surgeries has increased significantly in the past few years. Advantages such as fewer post-surgery complications and side effects, shorter patient recovery time, and decreased hospital stay are encouraging patients to opt for minimally invasive surgeries. Hence, rising demand for minimally invasive surgeries is expected to drive the autologous matrix-induced chondrogenesis market during the forecast period.

Autologous matrix-induced chondrogenesis is a one-step minimal invasive technique. Combined with microfracturing, it reduces the cost of microfracturing as compared to conventional microfacturing techniques and alternatives for treatment of chondral and osteochondral lesions. Hence, cost-efficiency of autologous matrix-induced chondrogenesis is likely to fuel the growth of the market in the next few years.

Musculoskeletal conditions are a major burden on individuals, health care systems, and social care systems, with indirect costs being predominant. According to the World Health Organization, people aged 45 years and above in the U.S. and Europe show higher rates of osteoarthritis; 14.1% among men and 22.8% among women. Hence, growing prevalence of bone and joint disorders is likely to fuel the growth of the autologous matrix-induced chondrogenesis market in the near future.

Most of the countries have less or no reimbursement for autologous matrix-induced chondrogenesis products or procedures. Autologous matrix-induced chondrogenesis products or procedures are not reimbursed by several health insurance companies in Europe. There is no reimbursement in most of the developing countries such as India, Australia, and Brazil. Hence, lack of efficient reimbursement is likely to hamper the growth of the autologous matrix-induced chondrogenesis market during the forecast period.

Autologous matrix-induced chondrogenesis is a recent technique, and hence does not have extensive clinical data. This is restraining physicians/doctors from adopting autologous matrix-induced chondrogenesis methods for treating patients suffering from bone and joint disorders. Hence, lack of extensive clinical data is likely to hamper the growth of the autologous matrix-induced chondrogenesis market in the next few years.

Segment analysis

Based on material type, the market has been segmented into Hyaluronic Acid, Collagen, Polyethylene glycol, polylactic-co-glycolic acid and others. The collagen segment held a major market share of 51.8% in 2015 due to high tensile strength and excellent handling properties. The hyaluronic acid segment is estimated to account for 22.6% of the global market in 2016 and is likely to register a CAGR of 8.9% during the forecast period. The PEG segment is projected to register a high CAGR of 11.1% during the forecast period due to their ability to be gelled into complex defects in situ using UV-light.

Regional analysis

The global Autologous Matrix-Induced Chondrogenesis market has been segmented into five major regions: North America, Latin America, Europe, Asia Pacific (APAC), and Middle East & Africa (MEA). In terms of value, North America is estimated to be the dominant market for global Autologous Matrix-Induced Chondrogenesis market in 2016 and expected to witness a CAGR of 8.3% over the forecast period. APAC is estimated to be the fastest growing markets in terms of CAGR. PEG segment in the North America Autologous Matrix-Induced Chondrogenesis market is expected to register a CAGR of 11.3% over the forecast period.

autologous matrix induced chondrogenesis market

Key market players

Some key players in the global Autologous Matrix-Induced Chondrogenesis market identified in this report are Anika Therapeutics, Inc., Arthro-Kinetics, B. Braun Melsungen AG, BioTissue AG, CartiHeal, Geistlich Pharma AG, JRI Orthopaedics Ltd., Matricel GmbH, Smith & Nephew plc, and Zimmer Biomet Holdings. The report also identifies company-specific strategies related to product development; market consolidation initiatives and analysis of their specific strengths, weaknesses, opportunities, and threats.

The global Autologous Matrix-Induced Chondrogenesis market is largely consolidated, with top ten players accounting for around 70.0% share in 2015. Market players such as Geistlich Pharma AG, Zimmer Biomet Holding, Smith & Nephew plc, B. Braun Melsungen AG, and Anika Therapeutics, Inc. dominated the global market in 2015. The company share of Geistlich Pharma AG in 2015 was valued at around 21%, thereby dominating the global Autologous Matrix-Induced Chondrogenesis market. Zimmer Biotech Holdings accounted for 13.5% market share in 2015, thereby holding the second largest market share followed by other players like Smith & Nephew plc, B. Braun Melsungen AG, and Anika Therapeutics, Inc.

Company Profiles

  • Anika Therapeutics, Inc. 
  • Arthro-Kinetics
  • B. Braun Melsungen AG 
  • BioTissue AG 
  • CartiHeal
  • Geistlich Pharma AG 
  • JRI Orthopaedics Ltd. 
  • Matricel GmbH 
  • Smith & Nephew plc 
  • Zimmer Biomet Holdings
  • Others.
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